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A novel repressor of P element transposition in Drosophila melanogaster

Published online by Cambridge University Press:  01 February 1998

RICHARD M. BADGE  and
JOHN F. Y. BROOKFIELD
RICHARD M. BADGE
Affiliation:
Department of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK
JOHN F. Y. BROOKFIELD
Affiliation:
Department of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK

Abstract

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We have discovered, in an inbred line (Loua) of Drosophila melanogaster from Zaïre, a third chromosome showing unusual P element repression. Repression of P element transposition by this chromosome, named Loua3, is dominant zygotic and has three unusual properties. Firstly, its repression of the gonadal dysgenesis caused by a strong P haplotype is strongly temperature-dependent, being most evident at higher rearing temperatures. Secondly, subdivision of Loua3 by recombination abolishes repression: the effect is apparently a function of the intact chromosome. Finally, Loua3 also diminishes somatic lethality when chromosomes carrying many ‘ammunition’ elements (Birmingham2) are exposed to the constitutive transposase source Δ2-3(99B). The chromosome has 17 P elements, none full-length, located in at least 12 dispersed positions.

Type
Research Article
Information
Genetics Research , Volume 71 , Issue 1 , February 1998 , pp. 21 - 30
Copyright
© 1998 Cambridge University Press