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A population genetical model for sequence evolution under multiple types of mutation

Published online by Cambridge University Press:  14 April 2009

Masaru Iizuka
Masaru Iizuka
Affiliation:
Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, U.S.A.

Summary

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DNA sequencing and restriction mapping provide us with information on DNA sequence evolution within populations, from which the phylogenetic relationships among the sequences can be inferred. Mutations such as base substitutions, deletions, insertions and transposable element insertions can be identified in each sequence. Theoretical study of this type of sequence evolution has been initiated recently. In this paper, population genetical models for sequence evolution under multiple types of mutation are developed. Models of infinite population size with neutral mutation, infinite population size with deleterious mutation and finite population size with neutral mutation are considered.

Type
Research Article
Information
Genetics Research , Volume 54 , Issue 3 , December 1989 , pp. 231 - 237
Copyright
Copyright © Cambridge University Press 1989

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