Hostname: page-component-848d4c4894-8bljj Total loading time: 0 Render date: 2024-06-29T21:08:51.709Z Has data issue: false hasContentIssue false
  • English
  • Français

Recombination between the t6 complex and linked loci in the house mouse

Published online by Cambridge University Press:  14 April 2009

Joseph H. Nadeau ,
Sandra J. Phillips  and
Igor K. Egorov
Joseph H. Nadeau
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
Sandra J. Phillips
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609
Igor K. Egorov
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Recombination between the t6 complex, three allozyme-encoding loci, two antigen-encoding loci, and four molecular markers was studied. The allozyme-encoding loci were complement component-3 (C-3), kidney catalase (Ce-2), and glyoxalase-1 (Glo-1); the antigen-encoding loci were the H-2 Class I genes H-2K and H-2D; the four molecular markers were Tu66, an α-globin pseudogene (Hba-4ps), an unidentified H-2 Class I gene, and the H-2 Class II gene I-Aβ. The latter six loci were used as markers for the t complex. Recombination was detected between Glo-1, Ce-2 and C-3, but not between the markers for the t complex Tu66, Hba-4ps, and the H-2 loci. These data indicate that Ce-2 and C-3 are located outside the t6 complex, while the latter are located within. These data also indicate that the telomeric boundary of the t6 complex is located between H-2 and Ce-2. Recently published studies have shown that complete gametic disequilibrium exists between the t complex and loci located centromeric to the H-2 - Ce-2 interval, while disequilibrium was not detected between loci located telomeric to this interval. Loci included within the region of recombination suppression are also those in disequilibrium with the t complex. As a result, recombination suppression probably resulting from chromosomal rearrangements associated with the t complex appears to be a sufficient explanation for the gametic disequilibrium observed between certain loci and the t complex.

Type
Research Article
Information
Genetics Research , Volume 45 , Issue 3 , June 1985 , pp. 251 - 264
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Alper, C. A. (1973). Genetics and C3 molecule. Vox Sanguinis 25, 1–8.Google ScholarPubMed
Alper, C. A. & Propp, R. P. (1968). Genetic polymorphisms of the third component of human complement (C3). Journal of Clinical Investigation 47, 2181–2191.CrossRefGoogle Scholar
Artzt, K., McCormick, P. & Bennett, D. (1982 a). Gene mapping within the T/t complex of the mouse. I. t–lethal genes are nonallelic. Cell 28, 463–470.Google Scholar
Artzt, K., Shin, H.-S. & Bennett, D. (1982 b). Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes. Cell 28, 471–476.CrossRefGoogle Scholar
Bennett, D. (1975). The T–locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Bennett, D., Alton, A. K. & Artzt, K. (1983). Genetic analysis of transmission ratio distortion by t–haplotypes in the mouse. Genetical Research 41, 29–45.Google Scholar
Bodmer, W. F. (1961). Effect of maternal age on the incidence of congenital abnormalities in mouse and man. Nature 190, 1134–1135.CrossRefGoogle Scholar
Choi, E., McIntyre, K., Germain, R. N. & Seidman, J. G. (1983). Murine I-Aβ chain polymorphism: nucleotide sequences of three allelic I-Aβ genes. Science 221, 283–286.CrossRefGoogle Scholar
Davisson, M. & Roderick, T. H. (1981). Recombination percentages. In Genetic Variants and Strains of the Laboratory Mouse, pp. 283–313. Stutgart: Gustav Fischer-Verlag.Google Scholar
Demin, Y. S. & Safronova, L. D. (1979). Effect of the female genotype on nonMendelian segregation in progeny of male carriers of t–haplotypes in the house mouse (Mus musculus). Doklady Biological Sciences 243, 582–584.Google Scholar
D'Eustachio, P., Fein, B., Michaelson, J. & Taylor, B. A. (1984). The α-globin pseudogene on mouse chromosome 17 is closely linked to H-2. Journal of Experimental Medicine 159, 958–963.Google Scholar
Evans, G. A., Margulies, D. H., Camerini-Otero, R. D., Ozato, K. & Seidman, J. G. (1982). Structure and expression of a mouse major histocompatibility antigen gene, H-2LD. Proceedings of the National Academy of Sciences U.S.A. 79, 1994–1998.Google Scholar
Fisher, R. A. (1949). A preliminary linkage test with agouti and undulated mice. Heredity 3, 229–241.CrossRefGoogle Scholar
Fox, H., Silver, L. M. & Martin, G. R. (1984). An alpha globin pseudogene is located within the mouse t complex. Immunogenetics 19, 125–130.Google Scholar
Green, M. C. & Snell, G. D. (1969). Personal communication. Mouse Newsletter 40, 29.Google Scholar
Hammerberg, C. & Klein, J. (1975 a). Linkage relationships of markers on Chromosome 17 of the house mouse. Genetical Research 26, 203–211.Google Scholar
Hammerberg, C. & Klein, J. (1975 b). Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse. Nature 258, 296–299.Google Scholar
Hauptfeld, V., Hammerberg, C.Klein, J. (1976). Histocompatibility-2 system in wild mice. III. Mixed lymphocyte reaction and cell-mediated lymphocytotoxicity with t–bearing mice. Immunogenetics 3, 489–497.Google Scholar
Ishii, K. & Charlesworth, B. (1977). Associations between allozyme loci and gene arrangements due to hitch-hiking effects of new inversions. Genetical Research 30, 93–106.Google Scholar
Klein, J. & Hammerberg, C. (1977). The control of differentiation by the T complex. Immunological Review 33, 70–104.Google Scholar
Levinson, J. R. & McDevitt, H. O. (1976). Murine t factors: an association between alleles at t and H-2. Journal of Experimental Medicine 144, 834–839.Google Scholar
Lyon, M. F. (1981). The t complex and the genetical control of development. Symposium of the Zoological Society of London 47, 455–477.Google Scholar
Lyon, M. F. (1984). Transmission ratio distortion in mouse t–haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37, 621–628.CrossRefGoogle ScholarPubMed
Maniatis, T., Jeffrey, A. & Kleid, D. G. (1975). Nucleotide sequence of the rightward operator of phage lambda. Proceedings of the National Academy of Sciences U.S.A. 72, 1184–1188.Google Scholar
Maniatis, T., Fritsch, E. F. & Sambrook, J. (1982). Large-scale isolation of plasmid DNA. In Molecular Cloning, A Laboratory Manual, pp. 86–96. New York: Cold Spring Harbor Laboratory.Google Scholar
Margulies, D. H., Evans, G. A., Flaherty, L. & Seidman, J. G. (1982). H-2- like genes in the Tla region of mouse chromosome 17. Nature 295, 168–170.Google Scholar
Nadeau, J. H., 1983. Absence of detectable gametic disequilibrium between the t complex and linked allozyme-encoding loci in house mice. Genetical Research 42, 323–333.Google Scholar
Oi, V. T., Jones, P. P., Goding, J., Herzenberg, L. A. & Herzenberg, L. A. (1978). Properties of monoclonal antibodies to mouse allotype, H-2 and I-A antigens. Current Topics in Microbiology and Immunology 81, 115–129.Google Scholar
Olds-Clarke, P. & McCabe, D. (1981). Genetic background affects expression of t haplotype in mouse sperm. Genetical Research 40, 249–254.CrossRefGoogle Scholar
Ozato, K., Mayer, N. & Sachs, D. H. (1980). Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and I-A antigens. Journal of Immunology 124, 533–540.CrossRefGoogle Scholar
Pizarro, O. & Dunn, L. C. (1970). A study of recombination between the H-2 (histocompatibility) locus and loci closely linked with it in the house mouse. Transplantation 9, 207–218.CrossRefGoogle ScholarPubMed
Reid, D. H. & Parsons, P. A. (1963). Sex of parent and variation of recombination with age in the mouse. Heredity 18, 107–108.Google Scholar
Robinson, R. R., Germain, R. N., McKean, D. J., Mescher, M. & Seidman, J. G. (1983). Extensive polymorphism surrounding the murine I-Aβ chain gene. Journal of Immunology 131, 2025–2031.Google Scholar
Röhme, D., Fox, H., Herrmann, B., Frischauf, A.-M., Edström, J.-E., Mains, P., Silver, M. & Lerach, H. (1984). Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell 36, 783–788.CrossRefGoogle Scholar
Rudolph, N. & Vandeberg, J. L. (1981). Linkage disequilibrium between the T/t complex and Pgk-2 in wild mice. Journal of Experimental Zoology 217, 455–458.Google Scholar
Shin, H.-S., Flaherty, L., Artzt, K., Bennett, D. & Ravetch, J. (1983). Inversion of the H-2 complex of t–haplotypes in mice. Nature 306, 380–383.CrossRefGoogle ScholarPubMed
Shin, H.-S., Bennett, D. & Artzt, K. (1984). Gene mapping within the T/t complex of the mouse. IV. The inverted MHC is intermingled with several t–lethal genes. Cell 39, 573–578.Google Scholar
Silver, L. M. & Artzt, K. (1981). Recombination suppression of mouse t haplotypes due to chromatin mismatching. Nature 290, 68–70.Google Scholar
Silver, L. M., White, M. & Artzt, K. (1980). Evidence for unequal crossing over within the mouse T/t complex. Proceedings of the National Academy of Sciences U.S.A. 77, 6077–6080.CrossRefGoogle ScholarPubMed
Snell, G. D. (1968). The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphisms. Folia Biologica 14, 335–358.Google Scholar
Southern, E. M. (1975). Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 98, 503–517.Google Scholar
Wallace, M. E. (1957). A balanced three-point experiment for linkage group V of the house mouse. Heredity 11, 223–258.Google Scholar
Wallace, M. E., MacSwiney, F. J. & Edwards, R. G. (1976). Parental age and recombination frequency in the house mouse. Genetical Research 28, 241–251.CrossRefGoogle ScholarPubMed