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The structure of hair and follicles of mice carrying the naked (N) gene

Published online by Cambridge University Press:  14 April 2009

Kathryn A. Raphael ,
R. E. Chapman ,
Penelope A. Frith  and
Pamela R. Pennycuik
Kathryn A. Raphael
Affiliation:
CSIRO, Genetics Research Laboratories, P.O. Box 184, North Ryde, N.S.W., 2113, Australia.
R. E. Chapman
Affiliation:
CSIRO, Division of Animal Production, P.O. Box 239, Blacktown, N.S.W., 2148, Australia
Penelope A. Frith
Affiliation:
CSIRO, Division of Animal Production, P.O. Box 239, Blacktown, N.S.W., 2148, Australia
Pamela R. Pennycuik
Affiliation:
CSIRO, Genetics Research Laboratories, P.O. Box 184, North Ryde, N.S.W., 2113, Australia.

Summary

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The hairs and follicles from mice carrying the naked (N) gene have been examined using both scanning and transmission electron microscopy in addition to light microscopy. Fibre cuticle cells and occasionally cortical cells were absent from the follicles of N / + mice when the base of the hair was growing. In N / N follicles there was a frequent lack of both cuticle and cortical cells throughout the growth phase of the follicles. Abnormalities were also observed in the manner in which the synthesized keratin was deposited in the fibres. The possible mode of action of the N gene is discussed in the light of these results.

Type
Research Article
Information
Genetics Research , Volume 39 , Issue 2 , April 1982 , pp. 139 - 148
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Auber, L. (1950). The anatomy of follicles producing wool-fibres, with special reference to keratinization. Transactions of the Royal Society of Edinburgh 62, 191–254.CrossRefGoogle Scholar
Bendit, E. G. & Gillespie, J. M. (1978). The probable role and location of high-glycine-tyrosineproteins in the structure of keratins. Biopolymers 17, 2743–2745.CrossRefGoogle ScholarPubMed
Chapman, R. E. & Black, J. L. (1981). Abnormal wool growth and alopecia of artificially reared lambs. Australian Journal of Biological Sciences 34, 11–26.CrossRefGoogle Scholar
Chapman, R. E. & Gemmell, R. T. (1971). The origin of cortical segmentation in wool follicles. Journal of Investigative Dermatology 57, 377–381.CrossRefGoogle ScholarPubMed
Chapman, R. E. & Reis, P. J. (1978). Effects of abomasal supplements of methionine on the wool follicles and skin of wheat-fed sheep. Australian Journal of Biological Sciences 31, 161–172.CrossRefGoogle ScholarPubMed
David, L. T. (1932). The external expression and comparative dermal histology of hereditary hairlessness in mammals. Zeitschrift für Zellforschung und Mikroskopische Anatomie 14, 616–710.CrossRefGoogle Scholar
Dry, F. W. (1926). The coat of the mouse (Mus musculus). Journal of Genetics 16, 287–340.CrossRefGoogle Scholar
Fraser, A. S. (1951). Growth of the mouse coat. Journal of Experimental Zoology 117, 15–29.CrossRefGoogle Scholar
Fraser, R. D. B., Gillespie, J. M. & MacRae, T. P. (1973). Tyrosine-rich proteins in keratins. Comparative Biochemistry and Physiology 44B, 943–947.Google ScholarPubMed
Frenkel, M. J., Gillespie, J. M. & Reis, P. J. (1974). Factors influencing the biosynthesis of the tyrosine-rich proteins of wool. Australian Journal of Biological Sciences 27, 31–38.CrossRefGoogle ScholarPubMed
Frenkel, M. J., Gillespie, J. M. & Reis, P. J. (1975). Studies on the inhibition of synthesis of the tyrosine-rich proteins of wool. Australian Journal of Biological Sciences 28, 331–338.CrossRefGoogle ScholarPubMed
Gillespie, J. M., Frenkel, M. J. & Reis, P. J. (1980). Changes in the matrix proteins of wool and mouse hair following the administration of depilatory compounds. Australian Journal of Biological Sciences 33, 125–136.CrossRefGoogle ScholarPubMed
Granholm, N. H., Stevens, L. C. & Theiler, K. (1979). Development of velvet coat (Ve / Ve), another early lethal mutation in the house mouse. Anatomy and Embryology 157, 237–242.CrossRefGoogle ScholarPubMed
Karnovsky, M. J. (1965). A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. Journal of Cell Biology 27, 137A–138A.Google Scholar
Lebedinsky, N. G. & Dauvart, A. (1927). Atrichosis und ihre Vererbung bei der albinotischen Hausmaus. Biologisches Zentralblatt 47, 748–752.Google Scholar
Oliver, R. F. (1970). The induction of hair follicle formation in the adult hooded rat by vibrissa dumal papillae. Journal of Embryology and Experimental Morphology 23, 219–236.Google Scholar
Peters, A., Proskauer, C. C. & Kaiserman-Abramof, I. R. (1968). The small pyramidal neuron of the rat cerebral cortex. Journal of Cell Biology 39, 604–619.CrossRefGoogle ScholarPubMed
Raphael, K. A. & Pennycuik, P. R. (1980). The site of action of the naked locus (N) in the mouse as determined by dermal-epidermal recombinations. Journal of Embryology and Experimental Morphology 57, 143–153.Google ScholarPubMed
Reynolds, E. S. (1963). The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. Journal of Cell Biology 17, 208–212.CrossRefGoogle ScholarPubMed
Short, B. F., Wilson, P. A. & Schinckel, P. G. (1965). Proliferation of follicle matrix cells in relation to wool growth. In Biology of the Skin and Hair Growth (ed. Lyne, A. G. and Short, B. F.), pp. 409–426. Sydney: Angus and Robertson.Google Scholar
Stieler, C. & Hollander, W. F. (1972). Location of the velvet coat mutant in linkage group VI of the mouse. Journal of Heredity 63, 212–214.CrossRefGoogle ScholarPubMed
Tenenhouse, H. S. & Gold, R. J. M. (1976). Loss of a homologue group of proteins in a dominantly inherited ectodermal malformation. Biochemical Journal 159, 149–160.CrossRefGoogle Scholar
Watson, M. L. (1958). Staining of tissue sections for electron microscopy with heavy metals. Journal of Biophysical and Biochemical Cytology 4, 475–478.CrossRefGoogle ScholarPubMed
Wilson, P. A. & Short, B. F. (1979). Cell proliferation and cortical cell production in relation to wool growth. Australian Journal of Biological Sciences 32, 317–327.CrossRefGoogle ScholarPubMed