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T(16: 17)43H translocation as a tool in analysis of the proximal part of chromosome 17 (including T-t gene complex) of the mouse*

Published online by Cambridge University Press:  14 April 2009

Jiří Forejt ,
Jana Čapková  and
Soňa Gregorová
Jiří Forejt
Affiliation:
Department of Developmental Genetics, Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Videňská 1083, 142 20 Prague 4, Czechoslovakia
Jana Čapková
Affiliation:
Department of Developmental Genetics, Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Videňská 1083, 142 20 Prague 4, Czechoslovakia
Soňa Gregorová
Affiliation:
Department of Developmental Genetics, Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Videňská 1083, 142 20 Prague 4, Czechoslovakia

Summary

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Linkage relationships of three gene markers of chromosome 17, namely Brachyury (T), tufted (tf), and Histocompatibility-2 (H-2), to the break-point of T(16; 17)43H male sterile translocation were established. The following order was found: T−tf−T43H−H-2. In all cases the translocation break was found in cis to H-2k, haplotype, no recombinant being found among 218 backcross individuals examined. More than 60 viable and fertile animals trisomic for the proximal part of chromosome 17 (including T-t genetic complex) have been recovered among progeny of T43H/+ female translocation heterozygotes as a result of adjacent −2 disjunction at first meiotic division. Mutation tf has been assigned to band 17B in chromosome 17 by comparing the location of T190Ca and T43H genetic and cytological breakpoints. Recombination between centromere 17 and T43H break was reduced almost to zero in the presence of Rb(16.17)7Bnr translocation. The unexpected restoration of male fertility was observed in T43H/Rb7Bnr hybrids (T43H/+ males being completely sterile) which made it possible to prepare the first homozygotes for T43H male–sterile translocation. Direct estimation of chiasma frequencies in centromere 17−T43H region indicated an 11 cM distance between the centromere 17 and the proximal end of t12 haplotype. The significance of centromere −t (or H-2) distance on the predictable restrictions of the possible haploid manifestation of T-t or H-2 gene products on sperm membrane is discussed.

Type
Research Article
Information
Genetics Research , Volume 35 , Issue 2 , April 1980 , pp. 165 - 177
Copyright
Copyright © Cambridge University Press 1980

References

REFERENCES

Baker, W. K. (1968). Position-effect variegation. Advances in Genetics 14, 133–169.CrossRefGoogle ScholarPubMed
Baranov, V. S. & Dyban, A. P. (1972). Embryonic damage of trisomic offsprings of mice with Robertsonian translocation (centric fusion T1 Iem. Archiv Anatomii Histologii i Embryologii 63, 67–77 (in Russian).Google Scholar
Beechey, C. V. & Searle, A. G. (1979). Private communication. Mouse News Letter, p. 59.Google Scholar
Bennett, D. (1975). The t-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Bennett, D., Artzt, K., Cookingham, J. & Calo, C. (1979). Recombinational analysis of the viable t-haplotype t38. Genetical Research 33, 269–277.CrossRefGoogle ScholarPubMed
Cattanach, B. M. (1978). Crossover suppression in mice heterozygous for tobacco mouse metacentrics. Cytogenetics and Cell Genetics 20, 264–279.CrossRefGoogle ScholarPubMed
Dyban, A. P. & Baranov, V. S. (1978). Cytogenetics of Development in Mammals. Nauka, Moscow (in Russian).Google Scholar
Eicher, E. M. & Washburn, L. (1977). Private communication. Mouse News Letter 56, 43.Google Scholar
Erickson, R. P. (1977). Gene expression of a region of chromosome 17 during murine spermatogenesis. Journal of Immunogenetics 4, 353–362.CrossRefGoogle ScholarPubMed
Evans, E. P., Breckon, G. & Ford, C. E. (1964). An air-drying method for meiotic preparations from mammalian testes. Cytogenetics 3, 289–294.CrossRefGoogle ScholarPubMed
Evans, E. P., Beechey, C. V. & Searle, A. G. (1977). Private communication. Mouse News Letter 57, 17.Google Scholar
Fellous, M., Erickson, R. P., Gachelin, G. & Jacob, F. (1976). The time of appearance of Ia antigens during spermatogenesis in the mouse. Transplantation 22, 440–444.CrossRefGoogle ScholarPubMed
Forejt, J. (1972). Chiasmata and crossing-over in the male mouse (Mus musculus). Suppression of recombination and chiasma frequencies in the ninth linkage group. Folia Biologica (Praha) 18, 161–170.Google ScholarPubMed
Forejt, J. (1973 a). Centromeric heterochromatin polymorphism in the house mouse. Evidence from inbred strains and natural populations. Chromosoma 43, 187–201.CrossRefGoogle ScholarPubMed
Forejt, J. (1973 b). Private communication. Mouse News Letter 49, 45.Google Scholar
Forejt, J. & Gregorová, S. (1977). Meiotic studies of translocations causing male sterility in the mouse. I. Autosomal reciprocal translocations. Cytogenetics and Cell Genetics 19, 159–179.CrossRefGoogle ScholarPubMed
Forejt, J. & Iványi, P. (1975). Genetic studies of male sterility of hybrids between laboratory and wild mice. (Mus musculus L.). Genetical Research 24, 189–206.CrossRefGoogle Scholar
Gachelin, G., Fellous, M., Guenet, J. L. & Jacob, F. (1976). Developmental expression of an early embryonic antigen common to mouse spermatozoa and cleavage embryos, and to human spermatozoa: its expression during spermatogenesis. Developmental Biology 50, 310–320.CrossRefGoogle ScholarPubMed
Gropp, A. (1975). Chromosomal animal model of human disease. Fetal trisomy and developmental failure. Teratology, pp. 17–31. Berlin: Springer-Verlag.CrossRefGoogle Scholar
Hammerberg, C. & Klein, J. (1975 a). Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse. Nature 258, 296–299.CrossRefGoogle Scholar
Hammerberg, C. & Klein, J. (1975 b). Linkage relationships of markers on chromosome 17 of the house mouse. Genetical Research 19, 203–211.CrossRefGoogle Scholar
Klein, J. (1971). Cytological identification of the chromosome carrying the IXth linkage group (including H-2) in the house mouse. Proceedings of the National Academy of Sciences, U.S.A. 68, 1594–1597.CrossRefGoogle ScholarPubMed
Klein, J. (1975). Biology of the Mouse Histocompatibility-2 Complex. New York: Springer-Verlag.CrossRefGoogle Scholar
Klein, J. & Hammerberg, C. (1977). The control of differentiation by the T complex. Immunological Reviews 33, 70–104.CrossRefGoogle ScholarPubMed
Klein, J. & Klein, D. (1972). Position of the translocation break T(2:9)138Ca in linkage group IX of the mouse. Genetical Research 19, 177–179.CrossRefGoogle Scholar
Lyon, M. F., Evans, E. P., Jarvis, S. E. & Sayers, I. (1979). t-haplotypes of the mouse may involve a change in intercalary DNA. Nature 279, 38–42.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1978). Private communication. Mouse News Letter 58, 44.Google Scholar
Lyon, M. F. & Philips, R. J. S. (1959). Crossing-over in mice heterozygous for t-alleles. Heredity 13, 23–32.CrossRefGoogle Scholar
Lyon, M. F. & Mason, I. (1977). Information on the nature of t haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genetical Research 29, 255–266.CrossRefGoogle Scholar
Lyon, M. F. & Meredith, R. (1964). Investigation of the nature of t-alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele. Heredity 19, 301–312.CrossRefGoogle ScholarPubMed
Micková, M. & Iványi, P. (1976). Study of H-2 antigens of wild mice (Mus musculus L.). Folia Biologica (Praha) 22, 169–189.Google Scholar
Polani, P. E., Crolla, D. A., Seller, M. J. & Moir, F. (1979). Meiotic crossing-over exchange in the female mouse visualized by BUdR substitution. Nature 278, 348–349.CrossRefGoogle ScholarPubMed
Searle, A. G., Beechy, C. V. & Evans, E. P. (1978). Meiotic effects in chromosomally derived sterility of mice. Annales de Biologie animale Biochemie et Biophysique 18 (2B), 391–398.CrossRefGoogle Scholar
Snell, G. D., Daussett, J. & Nathenson, S. G. (1976). Histocompatibility. New York: Academic Press.Google Scholar
Stimpfling, J. H. (1961). The use of PVP as a developing agent in mouse hemagglutination test. Transplantation Bulletin 27, 109–111.CrossRefGoogle Scholar
Tease, C. (1978). Cytological detection of crossing-over in BUdR substituted meiotic chromosomes using the fluorescent plus Giemsa technique. Nature 272, 823–824.CrossRefGoogle ScholarPubMed
Vojtíšková, M., Pokorná, Z., Viklický, V.Boubelík, M. & Hattikudur, N. S. (1974). The expression of H-2 and differentiation antigens on mouse spermatozoa. Folia Biologica (Praha) 20, 321–324.Google ScholarPubMed
Vojtíšková, M. & Pokorná, Z. (1972). Developmental expression of H-2 antigens in the spermatogenie cell series: possible bearing on haploid gene action. Folia Biologica (Praha) 18, 1–9.Google ScholarPubMed