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3-Methyl-4-Chlorophenol for Prion Decontamination of Medical Devices
Published online by Cambridge University Press: 21 June 2016
Abstract
Disinfectants containing 3-methyl-4-chlorophenol were tested for their capacity to inactivate the infectious agent of scrapie. Coincubation of brain homogenates prepared from terminally ill scrapie-infected hamsters with the disinfectants rendered the prion protein PrPSc sensitive to proteinase K digestion. Inoculation of hamsters with disinfectant-treated samples indicated a reduction in infectivity levels to below the limit of detection.
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- Copyright © The Society for Healthcare Epidemiology of America 2006
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