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The Epidemiology of Cytomegalovirus Infection Among Patients with Burns

Published online by Cambridge University Press:  21 June 2016

James F. Bale Jr. ,
G. Patrick Kealey ,
R. Michael Massanari  and
Ronald G. Strauss
James F. Bale Jr.
Affiliation:
Department of Pediatrics, The University of Iowa College of Medicine, Iowa City, Iowa
G. Patrick Kealey*
Affiliation:
Department of Surgery, The University of Iowa College of Medicine, Iowa City, Iowa
R. Michael Massanari
Affiliation:
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa
Ronald G. Strauss
Affiliation:
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
*
Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242
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Abstract

To determine the epidemiology of cytomegalovirus (CMV) infections among patients with burns, we prospectively studied 120 burn patients admitted to the University of Iowa Burn Center over a two-and-one-half year period. At the time of their admission, 44% of the patients had serologic evidence of prior CMV infection. Among 44 seropositive patients, 23 (52%) had four-fold or greater rises in CMV antibody titers. These patients had more severe burns (mean body surface area burn [BSAB] 26.8%) than those who did not exhibit titer rises (mean BSAB 16.2%, p=.04). Among 43 seronegative patients observed for at least 65 days after discharge from the center, eight (18.6%) seroconverted. Patients who seroconverted had longer hospital stays (p=.03), trends toward more severe burns p = .08) and a younger age (p = .15) than patients who remained seronegative. Despite frequent serologic evidence of CMV infection, CMV did not contribute, either directly or indirectly, to the morbidity or mortality of burns in these patients.

Type
Original articles
Information
Infection Control & Hospital Epidemiology , Volume 11 , Issue 1 , January 1990 , pp. 17 - 22
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1990

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