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Guideline implementation is effective at reducing proton pump inhibitor use in hematology-oncology units: A multidisciplinary intervention for reducing Clostridioides difficile risk

Published online by Cambridge University Press:  30 August 2019

Matthew J. Ziegler Open the ORCID record for Matthew J. Ziegler [Opens in a new window] ,
Craig Freyer ,
Daniel Landsburg ,
David Pegues ,
Warren Bilker ,
Rebecca Hirsh ,
Colleen Kucharczuk ,
Cheryl Gilmar ,
Theresa Gorman  and
Melissa Palmer
...Show all authors
Matthew J. Ziegler*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Craig Freyer
Affiliation:
Department of Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Daniel Landsburg
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
David Pegues
Affiliation:
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Healthcare Epidemiology, Infection Prevention and Control, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Warren Bilker
Affiliation:
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
Rebecca Hirsh
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Colleen Kucharczuk
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Cheryl Gilmar
Affiliation:
Department of Healthcare Epidemiology, Infection Prevention and Control, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Theresa Gorman
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Melissa Palmer
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Christina Harker
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Erin Lightheart
Affiliation:
Center for Clinical Effectiveness and Quality Improvement, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Jennifer H. Han
Affiliation:
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Healthcare Epidemiology, Infection Prevention and Control, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
*
Author for correspondence: Matthew J. Ziegler, E-mail: matthew.ziegler@uphs.upenn.edu
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Abstract

We implemented a guideline for appropriate acid suppressant use in hematology-oncology patients. This intervention resulted in a sustained reduction in proton pump inhibitor (PPI) use without an increase in rates of gastrointestinal bleeding. Practice guidelines are effective in reducing PPI use, which is associated with risk of Clostridioides difficile infection.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 11 , November 2019 , pp. 1294 - 1296
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

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Footnotes

PREVIOUS PRESENTATION. The interim results of this study were presented at the Society for Healthcare Epidemiology of America conference as an oral abstract presentation on April 26, 2019, in Boston, Massachusetts.

†

Present affiliation: GlaxoSmithKline, Rockville, Maryland

References

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