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Immunization with High-Dose Intradermal Recombinant Hepatitis B Vaccinein Healthcare Workers Who Failed to Respond to Intramuscular Vaccination

Published online by Cambridge University Press:  02 January 2015

Robert E. Levitz ,
Brian W. Cooper  and
Helen C. Regan
Robert E. Levitz
Affiliation:
Division of Infectious Diseases, Hartford Hospital, Hartford, andthe University of Connecticut Medical School, Farmington, Hartford, Connecticut
Brian W. Cooper*
Affiliation:
Division of Infectious Diseases, Hartford Hospital, Hartford, andthe University of Connecticut Medical School, Farmington, Hartford, Connecticut
Helen C. Regan
Affiliation:
Division of Employee Health, Hartford Hospital, Hartford, Connecticut
*
Division of Infectious Diseases, Hartford Hospital, 80 Seymour St., Hartford, CT 06102
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Abstract

Objective:

To achieve immunity to hepatitis B in healthcare workers who failed to respond to intramuscular vaccination and boosters.

Design:

An open prospective study of intradermal vaccination with recombinant hepatitis B vaccine.

Setting:

A large community hospital in Connecticut.

Participants:

Healthcare workers including physicians, nurses, and laboratory workers.

Results:

Immunization with high-dose intradermal recombinant hepatitis B vaccine, given in up to four doses, achieved immunity in 88% of healthcare workers who had previously been nonimmune.

Conclusions:

We conclude that intradermal vaccination is efficacious in the majority of healthcare workers who failed to respond to intramuscular vaccine. Further studies, including randomized comparisons with intramuscular vaccine as well as studies of cell-mediated immunity, appear warranted.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 16 , Issue 2 , February 1995 , pp. 88 - 91
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1995 

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