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HLA-Matched Donor Registries for Bone Marrow Transplants: A Decision Analysis

Published online by Cambridge University Press:  10 March 2009

Mark H. Eckman ,
Frank A. Sonnenberg ,
Itzhak Jacoby  and
Stephen G. Pauker
Mark H. Eckman
Affiliation:
Tufts University School of Medicine
Frank A. Sonnenberg
Affiliation:
Tufts University School of Medicine
Itzhak Jacoby
Affiliation:
National Institutes of Health, U.S.A.
Stephen G. Pauker
Affiliation:
Tufts University School of Medicine
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Extract

Bone marrow transplantation has become an accepted treatment for severe aplastic anemia, acute myelogenous leukemia, and acute lymphocytic leukemia (20;35). Less commonly thalassemia (23), multiple myeloma (25), severe combined immune deficiencies (10), and chronic granulocytic leukemia (14) are also treated with marrow transplantation. Most donors are siblings whose HLA phenotype is identical to the patient's. Such donors, however, are available to only one third of patients (6;16;27;28;35). In the absence of an HLA-identical sibling, partially matched, haplo-identical, related donors (differing by only one major histocom-patibility antigen) can be found for another 7% of patients (1;6;27;37). A variety of lower quality matches also can be found but have not been used extensively. Advances in tissue typing and the treatment of graft versus host disease now allow physicians to consider matched unrelated individuals as potential donors when a suitable related donor is not available (11;12;13;15;17;22).

Type
Special Section: Transplantation and Artificial Organs
Information
International Journal of Technology Assessment in Health Care , Volume 2 , Issue 3 , July 1986 , pp. 507 - 531
Copyright
Copyright © Cambridge University Press 1986

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References

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