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High rate of conversion to Alzheimer's disease in a cohort of amnestic MCI patients

Published online by Cambridge University Press:  01 February 2008

Klaus Schmidtke  and
Sonja Hermeneit
Klaus Schmidtke*
Affiliation:
Center for Geriatric Medicine and Gerontology, University Hospital Freiburg, Germany, and German Dementia Competence Network
Sonja Hermeneit
Affiliation:
Center for Geriatric Medicine and Gerontology, University Hospital Freiburg, Germany, and German Dementia Competence Network
*
Correspondence should be addressed to: Prof. Dr. K. Schmidtke, Centre for Geriatric Medicine and Gerontology Freiburg, Lehener Str. 88, 79106 Freiburg, Germany. Phone +49 761 2707077; Fax: +49 761 2707077. Email: klaus.schmidtke@uniklinik-freiburg.de.
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Abstract

Background: A large proportion of patients with amnestic mild cognitive impairment (MCI) progress to Alzheimer's disease (AD), but the rate of conversion is highly variable, depending on selection and inclusion criteria. In the present prospective study, amnestic MCI criteria were applied in order to enrich the study population with prodromal AD patients.

Methods: A composite CERAD word list learning z-score of −1 was applied as a cut-off for memory performance at baseline. Competing causes of memory impairment other than prodromal AD were actively excluded. A cohort of 88 amnestic MCI patients was included; 75 were available for follow-up.

Results: After a mean delay of 19 months, 44% were found to have converted to AD, corresponding to an annualized conversion rate of 28%. The rate of new diagnoses other than stable MCI or AD was 6%. Baseline neuropsychological variables were not instrumental to predict progression.

Conclusion: Amnestic MCI patients, as identified by the present set of criteria, carry a high risk of median-term progression to AD.

Keywords

amnestic MCIAlzheimer's diseasedementia
Type
Research Article
Information
International Psychogeriatrics , Volume 20 , Issue 1 , February 2008 , pp. 96 - 108
Copyright
Copyright © International Psychogeriatric Association 2007

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