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Hypertension and increased serum clozapine associated with clozapine and fluoxetine in combination
Published online by Cambridge University Press: 13 June 2014
Abstract
We report the case of a patient with schizophrenia who demonstrated increased serum clozapine and norclozapine levels in association with hypertension, when treated with fluoxetine and clozapine in combination.
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- Copyright © Cambridge University Press 1997
References
1.Kane, J, Honigfelt, G, Singer, Jet al.Clozapine for the treatment-resistant schizophrenic. Arch Gen Psych 1988; 45: 789–96.CrossRefGoogle ScholarPubMed
2.Goff, DC, Brotman, AW, Waites, M, Mc Cormack, S.Trial of fluoxetine added to neuroleptics for treatment resistant schizophrenic patients. Am J Psychiatry 1990; 147: 492–4.Google ScholarPubMed
3.Spina, E, De Domenico, P, Ruello, Cet al.Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients. Int Clin Psychopharmacol 1994; 9: 281–5.CrossRefGoogle ScholarPubMed
4.Cassady, SL, Thaker, GK. Addition of clozapine to fluoxetine [Letter]. Am J Psychiatry 1992; 149: 1274Google ScholarPubMed
5.Patel, B, Tandon, R. Development of obsessive-compulsive symptoms during clozapine treatment. Am J Psychiatry 1993; 150: 836.Google ScholarPubMed
6.Perry, PJ, Miller, D, Arndts, , et al.Clozapine and norclozapine plasma concentrations and clinical response of treatment refractory schizophrenic patients. Am J Psychiatry 1991; 148: 231–5.Google ScholarPubMed
7.Centorrino, F, Baldessarini, RJ, Kando, JCet al.Clozapine and metabolites: Concentrations in serum and clinical findings during treatment of chronically psychotic patients. J Clin Psychopharmacol 1994; 14: 119–25.CrossRefGoogle ScholarPubMed
8.Kingsbury, SJ, Puckett, KM. Serum concentrations of clozpine and its major metabolites: effects of cotreatment with fluoxetine or valproate: comment. Am J Psychiatry 1995; 152: 473.CrossRefGoogle Scholar
9.Cassady, SL, Thaker, GK. Addition of clozapine to fluoxetine (Letter). Am J psychiatry 1992; 149: 1274.Google Scholar
10.Patel, B, Tandon, R. Development of obsessive-compulsive symptoms during clozapine treatment. Am J Psychiatry 1993; 150: 836.Google ScholarPubMed
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