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Increase in immunoreactivity for endothelin-1 in blood vessels of rat liver metastases: experimental sarcoma and carcinoma

Published online by Cambridge University Press:  01 August 1997

A. LOESCH ,
M. TURMAINE ,
M. LOIZIDOU ,
R. CROWE ,
S. ASHRAF ,
I. TAYLOR  and
G. BURNSTOCK
A. LOESCH
Affiliation:
Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK
M. TURMAINE
Affiliation:
Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK
M. LOIZIDOU
Affiliation:
Department of Surgery, University College London, UK
R. CROWE
Affiliation:
Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK
S. ASHRAF
Affiliation:
Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK
I. TAYLOR
Affiliation:
Department of Surgery, University College London, UK
G. BURNSTOCK
Affiliation:
Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK
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Abstract

Using electron immunocytochemistry, blood vessels in the normal rat liver and in 2 different animal models of liver metastases: (1) Hooded Lister rat with MC28 tumour, a sarcoma, and (2) nude rat with HT29 tumour, a carcinoma, were investigated for the presence of endothelin-1. In the normal livers, small subpopulations of vascular endothelial cells displayed discrete immunoreactivity for endothelin-1. In the livers with malignant tumours, there was a substantial increase in endothelin-1-immunoreactive endothelial cells in vessels located at the tumour periphery. In the controls, antibody to endothelin-1 also labelled sporadically some fibroblast/fibroblast-like cells associated with the blood vessels. In contrast, intense immunoreactivity for endothelin-1 was frequently associated with the tumour cells and/or fibroblast cells in both types of tumour examined.

Keywords

Vasculatureendotheliumfibroblastsliver metastases
Type
Research Article
Information
The Journal of Anatomy , Volume 191 , Issue 2 , August 1997 , pp. 291 - 299
Copyright
© Anatomical Society of Great Britain and Ireland 1997

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