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An integrated theory of ageing in the nematode Caenorhabditis elegans

Published online by Cambridge University Press:  06 February 2001

DAVID GEMS
DAVID GEMS
Affiliation:
Department of Biology, University College London, UK
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Abstract

Numerous theories of ageing have been proposed, and many have been tested experimentally, particularly using nematode models such as Caenorhabditis elegans. By combining those theories of ageing that remain plausible with recent findings from studies of C. elegans life span mutants, an integrated theory of ageing has been devised. This is formed from 3 interconnected elements: the evolutionary theory of ageing, the oxidative damage theory of ageing, and a nonadaptive programmed ageing theory. This tripartite theory of ageing gives rise to a number of predictions that may be tested experimentally.

Keywords

Theories of ageingoxidative damageprogrammed ageingevolutionary theory of ageingCaenorhabditis elegansnematode
Type
Research Article
Information
The Journal of Anatomy , Volume 197 , Issue 4 , November 2000 , pp. 521 - 528
Copyright
© Anatomical Society of Great Britain and Ireland 2000

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