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Axon guidance of outgrowing corticospinal fibres in the rat

Published online by Cambridge University Press:  01 January 1999

ELBERT A. J. JOOSTEN
Affiliation:
Department of Neurology, Laboratory of Experimental Neurology, Academic Hospital Utrecht, The Netherlands
DOP P. R. BÄR
Affiliation:
Department of Neurology, Laboratory of Experimental Neurology, Academic Hospital Utrecht, The Netherlands
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Abstract

This review is concerned with the development of the rat corticospinal tract (CST). The CST is a long descending central pathway, restricted to mammals, which is involved both in motor and sensory control. The rat CST is a very useful model in experimental research on the development of fibre systems in mammals because of its postnatal outgrowth throughout the spinal cord as well as its experimental accessibility. Hence mechanisms underlying axon outgrowth and subsequent target cell finding can be studied relatively easily. In this respect the corticospinal tract forms an important example and model system for the better understanding of central nervous system development in general.

Type
Review
Copyright
© Anatomical Society of Great Britain and Ireland 1999

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