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Catecholamines, oxytocin and milk removal in dairy cows

Published online by Cambridge University Press:  01 June 2009

Jürg W. Blum ,
Dieter Schams  and
Rupert Bruckmaier
Jürg W. Blum
Affiliation:
Institute of Animal Science, Federal Institute of Technology, 8092 Zürich, Switzerland
Dieter Schams
Affiliation:
Institute of Physiology, Technical University of Munich, 8055 Freising – Weihenstephan, FRG
Rupert Bruckmaier
Affiliation:
Institute of Physiology, Technical University of Munich, 8055 Freising – Weihenstephan, FRG
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Summary

Experiments were designed to study the effects of catecholamines on oxytocin responses and milk removal in dairy cows. Adrenalin, noradrenalin, dopamine, isoproterenol (a β-adrenoceptor agonist), phentolamine (an α-adrenergic blocker) and propranolol (a β-adrenergic blocker) were infused intravenously. In addition, adrenalin was infused together with phentolamine and/or propranolol. Infusions started 8 min before milking and lasted until the end of milking. In some cases electroshocks (for 5 s) were applied immediately before milking in the absence and presence of phentolamine and propranolol. Adrenalin, noradrenalin and dopamine reduced milk removal, but only if administered in supraphysiological amounts. The effect of adrenalin and electroshocks on milk removal could be inhibited by α-, but not by β-adrenergic blockade. The effect of dopamine could be inhibited only partly by phentolamine. Inhibition of milk removal was not mediated by reduced oxytocin responses. Enhanced local release of catecholamines from sympathetic nerves was presumably responsible for lowered milk removal in response to electroshocks. Milk removal was facilitated during α-adrenergic blockade and during β-adrenoceptor stimulation.

Type
Original Articles
Information
Journal of Dairy Research , Volume 56 , Issue 2 , May 1989 , pp. 167 - 177
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

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References

REFERENCES

Aulsebrook, L. H. & Holland, R. C. 1969 Central inhibition of oxytocin release. American Journal of Physiology 216 830–842CrossRefGoogle ScholarPubMed
Bernabé, J. & Peeters, G. 1980 Studies on the motility of smooth muscles of the teats in lactating cows. Journal of Dairy Research 47 259–275CrossRefGoogle ScholarPubMed
Bernabé, J. & Ricordel, M.-J. 1985 a [Changes in the conditions of milk extraction caused by a β-receptor agonist (isoprenaline) injected into the jugular vein during machine milking of the cow.] Reproduction, Nutrition, Développement 25 61–74CrossRefGoogle Scholar
Bernabé, J. & Ricordel, M.-J. 1985 b [Effects of adrenalin and phenylephrine on milk extraction during machine milking of cows.] Reproduction, Nutrition, Développement 25 379–388CrossRefGoogle Scholar
Blum, J. W. 1984 Insulin suppressive effects of aminotetraline analogs and of dopamine. European Journal of Pharmacology 105 239–244CrossRefGoogle ScholarPubMed
Blum, J. W., Bianca, W., Näf, F., Kunz, P., Fischer, J. A. & Da Prada, M. 1979 Plasma catecholamine and parathyroid hormone responses in cattle during treadmill exercise at simulated high altitude. Hormone and Metabolic Research 11 246–251CrossRefGoogle ScholarPubMed
Blum, J. W., Guillebeau, A., Binswanger, U., Kunz, P., Da Prada, M. & Fischer, J. A. 1978 Effects of alpha-adrenergic stimulation and blockade on plasma parathyroid hormone concentrations in cows. Acta Endocrinologica 88 535–544Google ScholarPubMed
Blum, J. W., Kunz, P., Fischer, J. A., Binswanger, U., Lichtensteiger, W. & Da Prada, M. 1980 Parathyroid hormone response to dopamine in cattle. American Journal of Physiology 239 E255–E264Google ScholarPubMed
Dhondt, G., Houvenaghel, A., Peeters, G. & Verschooten, F. 1973 Influence of vasoactive hormones on blood flow through the mammary artery in lactating cows. Archives Internationales de Pharmacodynamie 204 89–104Google ScholarPubMed
Falck, B., Nystedt, T., Rosengren, E. & Stenflo, J. 1964 Dopamine and mast cells in ruminants. Acta Pharmacologica et Toxicologica 21 51–58CrossRefGoogle ScholarPubMed
Fröhli, D. & Blum, J. W. 1988 Blood levels, clearance rates and effects of epinephrine and norepinephrine on insulin and metabolites during alpha- and beta-adrenergic blockade in cattle in vivo, and in vitro degradation of dopamine in bovine blood. Acta Endocrinologica 118 245–253Google ScholarPubMed
Goodman, G. T. & Grosvenor, C. E. 1983 Neuroendocrine control of the milk ejection reflex. Journal of Dairy Science 66 2226–2235CrossRefGoogle ScholarPubMed
Gorewit, R. C. & Aromando, M. C. 1985 Mechanisms involved in the adrenalin-induced blockade of milk ejection in dairy cattle. Proceedings of the Society for Experimental Biology and Medicine 180 340–347CrossRefGoogle Scholar
Gorewit, R. C. & Scott, N. R. 1986 Cardiovascular responses of cows given electrical current during milking. Journal of Dairy Science 69 1122–1127CrossRefGoogle ScholarPubMed
Gorewit, R. C., Wachs, E. A., Sagi, R. & Merrill, W. G. 1983 Current concepts on the role of oxytocin in milk ejection. Journal of Dairy Science 66 2236–2250CrossRefGoogle ScholarPubMed
Hamann, J. 1981 [The influence of a β2-mimetic active substance (Planipart) on the milking behaviour of cows.] Tierärztliche Umschau 36 287–290Google Scholar
Henke Drenkard, D. V., Gorewit, R. C., Scott, N. R. & Sagi, R. 1985 Milk production, health, behavior, and endocrine responses of cows exposed to electrical current during milking. Journal of Dairy Science 68 2694–2702CrossRefGoogle ScholarPubMed
Lefcourt, A. M. 1982 a Rhythmic contractions of the teat sphincter in bovines: an expulsion mechanism. American Journal of Physiology 242 R181–R184Google ScholarPubMed
Lefcourt, A. M. 1982 b Effect of teat stimulation on sympathetic tone in bovine mammary gland. Journal of Dairy Science 65 2317–2322CrossRefGoogle ScholarPubMed
Lefcourt, A. M. & Akers, R. M. 1982 Endocrine responses of cows subjected to controlled voltages during milking. Journal of Dairy Science 65 2125–2130CrossRefGoogle ScholarPubMed
Lefcourt, A. M. & Akers, R. M. 1983 Is oxytocin really necessary for efficient milk removal in dairy cows? Journal of Dairy Science 66 2251–2259CrossRefGoogle ScholarPubMed
Lefcourt, A. M. & Akers, R. M. 1984 Small increases in peripheral noradrenaline inhibit the milk-ejection response by means of a peripheral mechanism. Journal of Endocrinology 100 337–344CrossRefGoogle ScholarPubMed
Lefcourt, A. M., Akers, R. M., Miller, R. H. & Weinland, B. 1985 Effects of intermittent electrical shock on responses related to milk ejection. Journal of Dairy Science 68 391–401CrossRefGoogle ScholarPubMed
Lincoln, D. W. & Paisley, A. C. 1982 Neuroendocrine control of milk ejection. Journal of Reproduction and Fertility 65 571–586CrossRefGoogle ScholarPubMed
Mayer, H., Schams, D., Prokopp, A. & Worstorff, H. 1984 Effects of manual stimulation and delayed milking on secretion of oxytocin and milking characteristics in dairy cows. Milchwissenschaft 39 666–670Google Scholar
Mena, F., Pacheco, P., Aguayo, D., Clapp, C. & Grosvenor, C. E. 1978 A rise in intramammary pressure follows electrical stimulation of mammary nerve in anesthetized rats. Endocrinology 103 1929–1936CrossRefGoogle ScholarPubMed
Mena, F., Pacheco, P., Aguayo, D., Martinez, G. & Grosvenor, C. E. 1979 Reflex regulation of autonomic influences upon the oxytocin-induced contractile response of the mammary gland in the anesthetized rat Endocrinology 104 751–756CrossRefGoogle ScholarPubMed
Mielke, H. 1981 [Recent results from studies on inhibited milk ejection.] Monatshefte für Veterinärmedizin 36 525–530Google Scholar
Moos, F., Freund-Mercier, M. J. & Richard, P. 1983 [Aminergic and peptidergic control of neurosecretory bursts in oxytocin cells during suckling.] In Multihormonal Regulations in Neuroendocrine Cells pp. 121–144 (Eds Tixier-Vidal, A. and Richard, P.) Paris: INSERM (Colloques INSERM No. 110, 1982)Google Scholar
Peeters, G., Coussens, R. & Sierens, G. 1949 Physiology of the nerves in the bovine mammary gland. Archives Internationales de Pharmacodynamie et de Thérapie 79 75–82Google ScholarPubMed
Peeters, G. & De Bruycker, R. 1975 Influence of sympathomimetic drugs on the motility of bovine teat muscles. Journal of Dairy Research 42 11–19CrossRefGoogle ScholarPubMed
Peeters, G., Petré, P. & Quintelier, W. 1977 Nature of adrenoceptor sites in bovine teat muscles. Naunyn-Schmiedebergs Archives of Pharmacology 296 111–115CrossRefGoogle ScholarPubMed
Sagi, R., Gorewit, R. C., Merrill, W. G. & Wilson, D. B. 1980 Premilking stimulation effects on milk performance and oxytocin and prolactin release in cows. Journal of Dairy Science 63 800–806CrossRefGoogle ScholarPubMed
Sambraus, H. H. 1971 [Rhythmic contractions of the bovine teat.] Zentralblatt für Veterinärmedizin 18A 335–340Google Scholar
Schams, D. 1983 Oxytocin determination by radioimmunoassay. III. Improvement to subpicogram sensitivity and application to blood levels in cyclic cattle. Acta Endocrinologica 103 180–183Google ScholarPubMed
Schams, D., Mayer, H., Prokopp, A. & Worstorff, H. 1984 Oxytocin secretion during milking in dairy cows with regard to the variation and importance of a threshold level for milk removal. Journal of Endocrinology 102 337–343CrossRefGoogle Scholar
Seybold, V. S., Miller, J. W. & Lewis, P. R. 1978 Investigation of a dopaminergic mechanism for regulating oxytocin release. Journal of Pharmacology and Experimental Therapeutics 207 605–610Google ScholarPubMed
Vandeputte-Van Messom, G., Bernabé, J., Burvenich, C. & Peeters, G. 1982 Effects of α-blocking agents on teat motility in lactating cows. Archives Internationales de Pharmacodynamie 260 309–311Google ScholarPubMed
Vandeputte-Van Messom, G., Bernabé, J., Burvenich, C. & Peeters, G. 1984 b Effect of prazosin on the function of the teat sphincter in lactating cows. Journal of Dairy Research 51 219–226CrossRefGoogle ScholarPubMed
Vandeputte-Van Messom, G., Burvenich, C. & Peeters, G. 1984 a Action of epinephrine on the function of the teat sphincter in the lactating cow. American Journal of Veterinary Research 45 2145–2149Google ScholarPubMed