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Human β-casein

Published online by Cambridge University Press:  01 June 2009

Rae Greenberg
Affiliation:
Eastern Regional Research Center*, Philadelphia, Pennsylvania 19118, USA
Merton L. Groves
Affiliation:
Eastern Regional Research Center*, Philadelphia, Pennsylvania 19118, USA

Summary

Human β-casein occurs in multiphosphorylated forms having the same amino acid composition but with 0–5 phosphate groups/molecule. Sequence analysis was used to determine whether each of the phosphorylated forms is a mixture of species having a certain number of phosphate groups randomly distributed or whether each form contains phosphate groups on specific seryl or threonyl residues. It was found that forms containing 2, 4 and 5 phosphate groups/molecule are homogeneous with respect to their phosphorylation sites. The monophosphorylated form, however, is a mixture of equal amounts of species phosphorylated at residues 9 or 10.

Type
Section B. Milk Proteins: Comparative Aspects, and the Study of some of the Minor Caseins
Copyright
Copyright © Proprietors of Journal of Dairy Research 1979

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