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Phosphorylation of casein components by Tyrosine-specific protein kinases

Published online by Cambridge University Press:  01 June 2009

Masaaki Yoshikawa ,
Masamitsu Shimada ,
Tsuyoshi Miyamura ,
Tatsuo Takeya  and
Hideo Chiba
Masaaki Yoshikawa
Affiliation:
Department of Food Science and Technology, Kyoto University, Kyoto 606
Masamitsu Shimada
Affiliation:
Department of Food Science and Technology, Kyoto University, Kyoto 606
Tsuyoshi Miyamura
Affiliation:
Department of Food Science and Technology, Kyoto University, Kyoto 606
Tatsuo Takeya
Affiliation:
Research Institute for Chemistry, Kyoto University, Uji 611, Japan
Hideo Chiba
Affiliation:
Department of Food Science and Technology, Kyoto University, Kyoto 606
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Summary

The phosphorylation of different caseins by a number of tyrosine-specific kinases has been studied. The different kinases showed a range of specificities, suggesting differences in recognition mechanisms. The site of phosphorylation of αs2-casein by one phosphorylase has been identified, and compared with analogous sites in other proteins.

Type
Original Articles
Information
Journal of Dairy Research , Volume 56 , Issue 3: Special Issue: Proceedings of the Hannah Research Institute Casein Conference , May 1989 , pp. 399 - 402
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

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References

REFERENCES

Bingham, E. W., Farrell, H. M. Jr, & Basch, J. J. 1982 Phosphorylation of casein, role of the Golgi apparatus. Journal of Biological Chemistry 247 8193–8194CrossRefGoogle Scholar
Brautigan, D. L., Bornstein, P. & Gallis, B. 1981 Phosphotyrosyl-protein phosphatase. Journal of Biological Chemistry 256, 6519–6522CrossRefGoogle ScholarPubMed
Frakenkel-Conrat, H. & Olcott, H. S. 1945 Esterification of proteins with alcohols of low molecular weight. Journal of Biological Chemistry 161, 259–268CrossRefGoogle Scholar
Hathaway, G. M. & Traugh, J. A. 1982 Casein kinases-multipotential protein kinases. Current Topics in Cellular Regulation, 21, 101–127CrossRefGoogle ScholarPubMed
Hunter, T. & Sefton, B. M. 1980 Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proceedings of the National Academy of Sciences U.S.A. 77, 1311–1315CrossRefGoogle ScholarPubMed
Ira, H., Takeya, T., Cross, F. R., Hanafusa, T. & Hanafusa, H. 1984 Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken emhryo fibroblasts. Proceedings of the National Academy of Sciences U.S.A. 81 4424–4428Google Scholar
Kasuga, M., Zick, Y., Blithe, D. L., Crettaz, M. & Kahn, G. R. 1982 Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free System. Nature 298 667–669CrossRefGoogle Scholar
Klein, H. H., Frbidenbero, G. R., Cordera, R. & Olefsky, J. M. 1985 Substrate specificities of insulin and epidermal growth factor receptor kinases. Biochemical and Biophysical Research Communications 127 254–263CrossRefGoogle ScholarPubMed
Nishimura, J., Huang, J. S. & Deuel, T. F. 1982 Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes. Proceedings of the National Academy of Sciences USA 79 4304–4307CrossRefGoogle ScholarPubMed
Swarup, G., Dasgupta, J. D. & Garbas, D. L. 1983 Tyrosine protein kinase activity of rat spleen and other tissues. Journal of Biological Chemistry 258 10341–10347CrossRefGoogle ScholarPubMed
Ushiro, H. & Cohen, S. 1980 Identification of phosphotyrosine as a product of epidermal growth factoractivated protein kinase in A-431 cell membranes. Journal of Biological Chemistry 255 8363–8365CrossRefGoogle ScholarPubMed
Wong, T. W. & Goldberd, A. R. 1983 Tyrosyl protein kinase in normal rat liver. Proceedings of National Academy of Sciences U.S.A. 80 2529–2533CrossRefGoogle ScholarPubMed
Yoshikawa, M., Tamaki, M., Sugimoto, E. & Chiba, H. 1974 Effect of dephosphorylation on the selfassociation and the precipitation of β-casein. Agricultural and Biological Chemistry 38 2051–2052Google Scholar