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Long-term effects of early overfeeding and food restriction during puberty on cardiac remodeling in adult rats

Part of: DOHaD Research in Latin-American

Published online by Cambridge University Press:  11 June 2020

Letícia Chavaglia Cavalet Open the ORCID record for Letícia Chavaglia Cavalet [Opens in a new window] ,
Larissa Cristina dos Santos Ribeiro ,
Gustavo Bergoli Rosa ,
Kássia Kristina Sousa ,
Aryanne Batista Soares de Melo ,
Dhiógenes Balsanufo Taveira Campos ,
Lucas Araújo Ferreira ,
Nathalia Oda Amaral ,
Yasmin Teixeira Viana Calisto  and
Alessandra Gisele de Castro
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Letícia Chavaglia Cavalet
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Larissa Cristina dos Santos Ribeiro
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Gustavo Bergoli Rosa
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Kássia Kristina Sousa
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Aryanne Batista Soares de Melo
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Dhiógenes Balsanufo Taveira Campos
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Lucas Araújo Ferreira
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Nathalia Oda Amaral
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Yasmin Teixeira Viana Calisto
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Alessandra Gisele de Castro
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Carlos Henrique de Castro
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Gustavo Rodrigues Pedrino
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
Rodrigo Mello Gomes*
Affiliation:
Department of Physiological Sciences, Federal University of Goiás, Goiânia, GO, Brazil
*
Address for correspondence: Rodrigo Mello Gomes, Laboratory of Endocrine Physiology and Metabolism (LabFEM), Department of Physiological Sciences (DCiF) – Biological Science Institute II (ICB-II), room 101, Federal University of Goiás (UFG) – Campus II, Esperança Avenue s/n, CEP: 74690-900, Goiânia, GO, Brazil. Email: rodrigomellogomes@hotmail.com
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Abstract

Nutritional disorders during the perinatal period cause cardiometabolic dysfunction, which is observable in the early overfeeding (EO) experimental model. Therefore, severe caloric restriction has the potential of affecting homeostasis through the same epigenetic mechanisms, and its effects need elucidation. This work aims to determine the impact of food restriction (FR) during puberty in early overfed obese and non-obese animals in adult life. Three days after delivery (PN3), Wistar rats were separated into two groups: normal litter (NL; 9 pups) and small litter (SL; 3 pups). At PN30, some offspring were subjected to FR (50%) until PN60, or maintained with free access to standard chow. NL and SL animals submitted to food restriction (NLFR and SLFR groups) were kept in recovery with free access to standard chow from PN60 until PN120. Body weight and food intake were monitored throughout the experimental period. At PN120 cardiovascular parameters were analyzed and the animals were euthanized for sample collection. SLNF and SLFR offspring were overweight and had increased adiposity. Differences in blood pressure were observed only between obese and non-obese animals. Obese and FR animals have cardiac remodeling showing cardiomyocyte hypertrophy and the presence of interstitial and perivascular fibrosis. FR animals also show increased expression of AT1 and AT2 receptors and of total ERK and p-ERK. The present study showed that EO leads to the obese phenotype and cardiovascular disruptions. Interestingly, we demonstrated that severe FR during puberty leads to cardiac remodeling.

Keywords

Obesitycardiometabolic programmingearly overfeedingfood restrictionrenin–angiotensin systemhypertension
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 5 , October 2020 , pp. 492 - 498
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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