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Intergenerational response of steroidogenesis-related genes to maternal malnutrition

Published online by Cambridge University Press:  21 February 2019

Abdel Halim Harrath Open the ORCID record for Abdel Halim Harrath [Opens in a new window] ,
Abdulkarem Alrezaki ,
Saleh H. Alwasel  and
Abdelhabib Semlali
Abdel Halim Harrath*
Affiliation:
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia Institute of Biological Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia
Abdulkarem Alrezaki
Affiliation:
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia
Saleh H. Alwasel
Affiliation:
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia
Abdelhabib Semlali
Affiliation:
Groupe de Recherche en Écologie Buccale, Département de stomatologie, Faculté de Médecine Dentaire, Université Laval, Québec, QC, Canada
*
Address for correspondence: Prof. A. H. Harrath, Department of Zoology, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. E-mail: hharrath@ksu.edu.sa
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Abstract

We sought to examine whether rat maternal food restriction (MFR) affects the expression of steroidogenesis-related genes Cyp19, Cyp17a1, Insl3 and Gdf-9 in the ovaries of offspring from the first (FRG1) and second (FRG2) generations at pre-pubertal age (week 4) and during adulthood (week 8). At week 4, MFR significantly increased the expression of RNAs for all analyzed genes in both FRG1 and FRG2 females, which may indicate that MFR affects the onset of the reproductive lifespan, by inducing early pubertal onset. At week 8, the Cyp19 gene was still upregulated in MRF-subjected animals (Cyp19: P=0.0049 and P=0.0508 in FRG1 and FRG2, respectively), but MFR induced a significant decrease in Cyp17 and Gdf-9 gene expression in the offspring of both FRG1 and FRG2 females when compared with the controls (Cyp17: P=0.0018 and P=0.0016, respectively; Gdf-9: P=0.0047 and P=0.0023, respectively). This suggests that females at week 8, which should normally be in their optimal reproductive capacity, experience premature ovarian aging. At week 4, the activation of Cyp19 and Cyp17 was higher in the FRG1 ovaries than in the FRG2 ovaries, whereas the extent of Insl3 and Gdf-9 activation was lower in the FRG1 ovaries. This may indicate that FRG2 females were more vulnerable to MFR than their mothers (FRG1) and grandmothers, which is consistent with the ‘predictive adaptive response’ hypothesis. Our findings reveal that MFR may induce intergenerational ovarian changes as an adaptive response to ensure reproductive success before death.

Keywords

early pubertymaternal food restrictionovarian agingovarysteroidogenesis
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 5 , October 2019 , pp. 587 - 594
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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