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Supplementation of the maternal diet with Brazil nut (Bertholletia excelsa H.B.K.) prevents cognitive impairment in the offspring of obese mothers

Published online by Cambridge University Press:  12 February 2024

Lilian Fioravanso Apolinário ,
Amanda Tais Silva ,
Andrielli Pompermayer Rosa ,
Cleber da Silva Oliveira ,
Cleberson Lira ,
João Pedro Costa dos Santos Guerra ,
Júlia Furtado Friedrich ,
Letícia Queiroz Rosa ,
Rodrigo Chelegão  and
Sílvia de Carvalho Campos Botelho
...Show all authors
Lilian Fioravanso Apolinário
Affiliation:
Programa de Pós-Graduação em Ciências em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Amanda Tais Silva
Affiliation:
Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Andrielli Pompermayer Rosa
Affiliation:
Laboratórios Integrados de Pesquisas Químicas, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Cleber da Silva Oliveira
Affiliation:
Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Cleberson Lira
Affiliation:
Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
João Pedro Costa dos Santos Guerra
Affiliation:
Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Júlia Furtado Friedrich
Affiliation:
Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Letícia Queiroz Rosa
Affiliation:
Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Rodrigo Chelegão
Affiliation:
Embrapa Agrosilvipastoril, Sinop, MT, Brazil
Sílvia de Carvalho Campos Botelho
Affiliation:
Embrapa Agrosilvipastoril, Sinop, MT, Brazil
Valéria Dornelles Gindri Sinhorin
Affiliation:
Laboratórios Integrados de Pesquisas Químicas, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
Júlio Cezar de Oliveira
Affiliation:
Programa de Pós-Graduação em Ciências em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil Grupo de Pesquisa Programação Perinatal de Doenças Metabólicas, conceito DOHaD, Laboratório de Doenças Metabólicas e Cardiovasculares, Núcleo de Pesquisa e Apoio Didático em Saúde, Sinop, MT, Brazil
Nádia Aléssio Velloso*
Affiliation:
Programa de Pós-Graduação em Ciências em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil Núcleo de Pesquisa e Apoio Didático em Saúde, Universidade Federal de Mato Grosso (UFMT), Sinop, MT, Brazil
*
Corresponding author: N. A. Velloso; Email: na.velloso@gmail.com
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Abstract

Maternal obesity may trigger long-term neurodevelopmental disorders in offspring. Considering the benefits of the Brazil nut (Bertholletia excelsa H.B.K.), a rich source of nutrients such as selenium, this study aimed to evaluate its effect on the behavior of obese rat offspring and its relationship with oxidative stress. From 60 days of age until weaning, female Wistar rats were fed a high-fat diet (mHF) or an HF diet supplemented with 5% Brazil nut (mHF/BN), while control mothers (mCTL) were fed a standard diet or a standard diet supplemented with 5% Brazil nut (mBN). Male pups received a standard diet throughout life and, at 30 and 90 days old, were subjected to behavioral tasks to evaluate anxiety and cognition. Biochemical evaluations were performed at 90 days of age. No alterations were observed in the anxiety behavior of the offspring. However, the offspring of the mHF group (oHF) exhibited impaired short-term memory at 30 and 90 days of age and impaired long-term memory at 30 days. Short-term memory impairment was prevented by Brazil nuts in young rats (30 days). While the serum selenium concentration was reduced in the oHF group, the serum catalase concentration was reduced in all groups, without changes in lipid peroxidation or protein carbonylation. Brazil nut maternal diet supplementation prevented short- and long-term cognitive impairment in the offspring, which may be related to the selenium levels.

Keywords

Brazil nutneurodevelopmentmemoryoxidative stressobesity
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 14 , Issue 6 , December 2023 , pp. 795 - 804
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Copyright
© The Author(s), 2024. Published by Cambridge University Press in association with The International Society for Developmental Origins of Health and Disease (DOHaD)

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