Utilizing a large volume of archival documents, this study establishes for the first time the long-term trends in real wages of skilled and unskilled construction workers in Istanbul and other Ottoman cities in southeastern Europe and the Middle East, from the second half of the fifteenth century until World War I. A detailed consumer price index and nominal wage indices are constructed for the city of Istanbul for this purpose. These price and wage series are then inserted into a larger framework of price and wage trends in European cities during the same period.