This work is an experimental study of the deformation and breakup of a bubble in a turbulent flow. A special facility was designed to obtain intense turbulence without significant mean flow. The experiments were performed under microgravity conditions to ensure that turbulence was the only cause of bubble deformation. A scalar parameter, characteristic of this deformation, was obtained by video processing of high-speed movies. The time evolution and spectral representation of this scalar parameter showed the dynamical characteristics of bubble deformation. The signatures of the eigenmodes of oscillation predicted by the linear theory were clearly observed and the predominance of the second mode was proved. In addition, numerical simulations were performed by computing the response of a damped oscillator to the measured turbulence forcing. Simulations and experiments were found to be in good agreement both qualitatively, from visual inspections of the signals, and quantitatively, from a statistical analysis. The role of bubble dynamics in the deformation process has been clarified. On the one hand, the time response of the bubble controls the maximum amount of energy which can be extracted from each turbulent eddy. On the other hand, the viscous damping limits the energy that the bubble can accumulate during its fluctuating deformation. Moreover, two breakup mechanisms have been identified. One mechanism results from the balance between two opposing dominant forces, and the other from a resonance oscillation. A new parameter, the mean efficiency coefficient, has been introduced to take into account the various aspects of bubble dynamics. Used together with the Weber number, this parameter allows the prediction of the occurrence of these two mechanisms. Finally, the influence of the residence time of the bubble on the statistics of the deformation has been analysed and quantified.