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Experimental ancylostomiasis in Swiss albino mice: adrenal and thyroid histopathology

Published online by Cambridge University Press:  05 June 2009

Ismail Bhai  and
A. K. Pandey
Ismail Bhai
Affiliation:
Endocrinology Unit, School of Studies in Zoology, Vikram University, Ujjain 456010, India
A. K. Pandey
Affiliation:
Endocrinology Unit, School of Studies in Zoology, Vikram University, Ujjain 456010, India
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Abstract

Remarkable hypertrophic changes were observed in the adrenal and thyroid glands of male mice after 7 to 16 days of infection with the filariform larvae of Ancylostoma caninum, but not in females. The adrenal gland revealed enormous enlargement of cells in the zonae glomerulosa, fasciculata and medulla, and also the formation of big vacuoles in the glomerular zone, whereas the thyroid gland showed distinctly hypcrtrophicd follicular epithelium with marked acolloidal condition and follicular mass formation. These changes in the cellular diameter were highly significant (P>0·001 to <0·005). The possible reasons for hyperactivity of these glands are discussed.

Type
Research Article
Information
Journal of Helminthology , Volume 55 , Issue 4 , December 1981 , pp. 295 - 305
Copyright
Copyright © Cambridge University Press 1981

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References

REFERENCES

Babonits, M, Wiener, F., Fazakas, B. & Bedo, A.(1968) Etudes histologiques et histochimiques de surrenales de cobayeo traitées par des extraits. Annales ile Parasitologie humaine et Comparéee, 43(4), 481–491.CrossRefGoogle Scholar
Challey, J. R., (1966) Changes in adrenal constituents and their relationship to corticosterone secretion in chickens selected for genetic resistance and susceptibility to cecal coccidiosis. Journal of Parasitology, 52, 967–974.CrossRefGoogle ScholarPubMed
Chatterji, A. & Sen Gupta, P. C. (1962) Adrenals in Trypanosoma evansi infection in white rats. Nature, 193, 78–79.CrossRefGoogle Scholar
Chowdhury, A. R, Deshmukh, M. B, Nashikkar, A. B.Raghuveeran, C. D. & Chatterjee, A. K. (1978) Cellular changes of adrenal under the acute stress of O-chlorobenzylidene malononitrilc (CS). Experientia, 34, 494–495.CrossRefGoogle ScholarPubMed
Cole, W. H, Womack, N. A, Gray, S. H. (1929) The thyroid in infections and toxemias. American Journal of Surgery, 6, 221–229.CrossRefGoogle Scholar
Collier, H. O. J., Fulton, J. D. & Innes, J. R. M. (1942) The oedema of mice infected with Trypanosoma cruzi and the accompanying pathological lesions. Annals of Tropical Medicine, 36, 137–150.Google Scholar
Goble, F. C. (1954) Thyroid changes in acute experimental Chagas' disease in dogs. American Journal of Pathology, 30, 599–607.Google ScholarPubMed
Goble, F. C. & Konopka, E. A. (1973) Sex as a factor in infectious disease. Transactions of the New York Academy of Sciences, 35, 325–346.CrossRefGoogle Scholar
Ismail, Bhai & Pandey, A. K. (1977) Adrenal medullary catecholamines in Swiss albino mice infected with Ancylostoma caninum. Bioresearch, 1, 75–77.Google Scholar
Ismail, Bhai and Pandey, A. K. (1978) Sex difference in hypothyroidism induced by a goitrogcn in Swiss albino mice. National Academy Science Letters, 1, 161.Google Scholar
Lomonaco, D. A, Oliveria, H. L.Kieffer, J. & Pieroni, R. R. (1966) Abnormal regulation of thyroid function in patients with chronic Chagas' disease. Acta Endocrinologica, 53, 162–176.Google Scholar
May, I., Jivanescu, I. & Pop, P. (1969) Morphological and functional investigations on the adrenal cortex in cattle infected with Fasciola hepatka. Lucrari Instituta Cercetari Veterinaria Bioprep. Pasteur, 6, 367–376. (From English summary.)Google Scholar
Means, J. H, Degroot, L. J. & Stanburg, J. B. (1963) The thyroid and its diseases. Third edition. McGraw-Hill, New York. xi + 618 pp.Google Scholar
Ray, D. K., Bhopale, K. K. & Shrivastava, V. B. (1972) Migration and growth of Ancylostoma ceylanicum in golden hamsters Mesocricetus anratus. Journal of Helminthology, 46, 357–362.CrossRefGoogle Scholar
Ray, D. K., Bhopale, K. K. & Shrivastava, V. B. (1977) Effect of hydrocortisone acetate on the development of Ancylostoma caninum in mice. Indian Journal of Parasitology, 1, 29–32.Google Scholar
Scott, J. A. (1928) An experimental study of the development of Ancylostoma caninum in normal and abnormal hosts. American Journal of Hygiene, 8, 158–209.Google Scholar
Sen, H. G., Joshi, U. N. & Seth, D. (1965) Effect of cortisone upon Ancylostoma caninum infection in albino mice. Transactions of the Royal Society of Tropical Medicine and Hygiene, 59, 684–689.CrossRefGoogle Scholar
Shoemaker, J. P., Hoffman, R. V. Jr, Walsh, E. L. & Blair, B. (1970) Trypanosoma cruzi: thyroid hyperplasia, hyperthyroidism and variance in thyroid function in mice. Experimental Parasitoloay, 27, 9–14.CrossRefGoogle ScholarPubMed
Shoemaker, J. P. (1975) Plasmodium berghei: thyroid hyperplasia and thyroid hyperactivity in mice. Experimental Parasitology, 37, 78–82.CrossRefGoogle ScholarPubMed
Tepperman, J., Engel, F. L. & Long, C. N. H. (1943) Endocrinology, 32, 373–402. (Cited by: Kass, E. H. & Finland, M., 1953, Adrenocortical hormones in infection and immunity. Annual Review of Microbiology, 7, 361–386.)Google Scholar
Wakelin, D. (1970) Studies on the immunity of albino mice to Trichuris muris. Suppression of immunity by cortisone acetate. Parasitology, 60, 229–237.CrossRefGoogle ScholarPubMed