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The immune response of male DSN hamsters to a primary infection with Ancylostoma ceylanicum

Published online by Cambridge University Press:  05 June 2009

Paul Garside ,
Jerzy M. Behnke  and
Richard A. Rose
Paul Garside
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
Jerzy M. Behnke*
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
Richard A. Rose
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
*
* Author to whom all correspondence should be addressed.
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Abstract

The immune response of hamsters to a chronic hookworm infection has been investigated. Ancylostoma ceylanicum caused long term infections in hamsters which were associated with prominent changes in secondary lymphoid organs. The mesenteric lymph nodes and spleens increased rapidly in size stabilizing at approximately 3–4 times the weight in control animals by weeks 3–7. Cells from both the mesenteric lymph node and spleen, after an initial period of increased blast cell activity, became less reactive in the latter stages of infection. Serum antibody responses were marked, commencing in weeks 3–4 and increasing in intensity throughout the 10 week period of measurement. The results are discussed in relation to their contribution to the understanding of human hookworm infection.

Keywords

Ancylostoma ceylanicumhamsterimmune responseprimary infection
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 3 , September 1989 , pp. 251 - 260
Copyright
Copyright © Cambridge University Press 1989

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