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Immunity to Trichuris muris in the laboratory mouse

Published online by Cambridge University Press:  12 April 2024

K.J. Else  and
M.L. deSchoolmeester
K.J. Else*
Affiliation:
School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
M.L. deSchoolmeester
Affiliation:
School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.
*
* Fax: 0161 275 5640 E-mail: kathryn.j.else@man.ac.uk.
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Abstract

Of all the laboratory models of intestinal nematode infection, Trichuris muris in the mouse is arguably the most powerful. This is largely due to the fact that the ability to expel this parasite is strain dependent. Thus, most mouse strains readily expel T. muris. However certain mouse strains, and indeed some individuals within particular mouse strains, are unable to mount a protective immune response and harbour long term chronic infections. This unique model thus presents an opportunity to examine the immune events underlying both resistance to infection and persistent infection within the same host species, and in some cases, the same host strain.

Type
Research Article
Information
Journal of Helminthology , Volume 77 , Issue 2 , June 2003 , pp. 95 - 98
Copyright
Copyright © Cambridge University Press 2003

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References

Arbour, N.C., Lorenz, E., Schutte, B.C., Zabner, J., Kline, J.N., Jones, M., Frees, K., Watt, J.L. & Schwartz, D.A. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics 25, 187–191.CrossRefGoogle ScholarPubMed
Artis, D., Humphreys, N.E., Bancroft, A.J., Rothwell, N.J., Potten, C.S. & Grencis, R.K. (1999) Tumor necrosis factor a is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. Journal of Experimental Medicine 190, 953–962.CrossRefGoogle ScholarPubMed
Baldini, M., Lohman, I.C., Halonen, M., Erickson, R.P., Holt, P.G. & Martinez, F.D. (1999) A polymorphism in the 5? flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. American Journal of Respiratory Cell and MolecularBiology 20, 976–983.CrossRefGoogle ScholarPubMed
Bancroft, A.J., Else, K.J., Sypek, J.P. & Grencis, R.K. (1997) Interleukin-12 promotes a chronic intestinal nematode infection. European Journal of Immunology 27, 866–870.CrossRefGoogle ScholarPubMed
Bancroft, A.J., McKenzie, A.N.J. & Grencis, R.K. (1998) A critical role for IL-13 in resistance to intestinal nematode infection. Journal of Immunology 160, 3453–3461.CrossRefGoogle ScholarPubMed
Betts, C.J. & Else, K.J. (1999) Mast cells, eosinophils and antibody mediated cytotoxicity are not critical in resistance to Trichuris muris . Parasite Immunology 21, 45–52.CrossRefGoogle Scholar
Betts, C.J., deSchoolmeester, M.L. & Else, K.J. (2000) Trichuris muris: CD4+ T cell mediated protection in reconstituted SCID mice. Parasitology 121, 631–637.Google ScholarPubMed
Bonecchi, R., Bianchi, G., Bordignon, P.P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P.A., Mantovani, A. & Sinigaglia, F. (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. Journal of Experimental Medicine 187, 129–134.CrossRefGoogle ScholarPubMed
Carmen, J.A., Pond, L., Nashold, F., Wassom, D.L. & Hayes, C.E. (1992) Immunity to Trichinella spiralis infection in vitamin A-deficient mice. Journal of Experimental Medicine 175, 111–120.CrossRefGoogle Scholar
Else, K.J. & Grencis, R.K. (1991) Cellular immune responses to the nematode parasite Trichuris muris I. Differential cytokine production during acute or chronic infection. Immunology 72, 508–513.Google Scholar
Else, K.J. & Grencis, R.K. (1996) Antibody independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris . Infection and Immunity 64, 2950–2954.CrossRefGoogle Scholar
Else, K.J. & Wakelin, D. (1988) The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice. Parasitology 96, 543–550.CrossRefGoogle ScholarPubMed
Else, K.J., Hultner, L. & Grencis, R.K. (1992) Cellular immune response to the nematode parasite Trichuris muris II. Differential induction of Th cell subsets in resistant and susceptible mice. Immunology 75, 232–237.Google Scholar
Else, K.J., Entwistle, G.M. & Grencis, R.K. (1993) Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris . Parasite Immunology 15, 595–600.CrossRefGoogle Scholar
Else, K.J., Finkelman, F.D., Maliszewski, C. & Grencis, R.K. (1994) Cytokine mediated regulation of chronic intestinal helminth infection. Journal of Experimental Medicine 179, 347–351.CrossRefGoogle ScholarPubMed
Faulkner, H., Humphreys, N., Renauld, J.C., Van Snick, J. & Grencis, R.K. (1997) Interleukin-9 is involved in host protective immunity to intestinal nematode infection. European Journal of Immunology 27, 2536–2540.CrossRefGoogle ScholarPubMed
Grencis, R.K., Reidlinger, J. & Wakelin, D. (1985) L3T4 positive lymphoblasts are responsible for the transfer of immunity to Trichinella spiralis in mice. Immunology 56, 213–218.Google ScholarPubMed
Helmby, H., Takeda, K., Akira, S. & Grencis, R.K. (2001) Interleukin-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13. Journal of Experimental Medicine 194, 355–364.CrossRefGoogle ScholarPubMed
Koyama, K., Tamanchi, H. & Ito, Y. (1995) The role of CD4+ and CD8+ T cells in protective immunity to the murine parasite Trichuris muris . Parasite Immunology 17, 161–165.CrossRefGoogle Scholar
Kunkel, E.J., Campbell, J.J., Haralsdsen, G., Pan, J., Boisvert, J., Roberts, A.I., Ebert, E.C., Vierra, M.A., Goodman, S.B., Genovese, M.C., Wardlaw, A.J., Greenberg, H.B., Parker, C.M., Butcher, E.C., Andrew, D.P. & Agace, W.W. (2000) Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguishes the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. Journal of Experimental Medicine 192, 761–767.CrossRefGoogle ScholarPubMed
Lee, T.D.G., Wakelin, D. & Grencis, R.K. (1983) Cellular mechanisms of immunity to the nematode Trichuris muris . International Journal for Parasitology 13, 349–353.CrossRefGoogle Scholar
Medzhitov, R. & Janeway, C. Jr (2000) Innate immune recognition: mechanisms and pathways. Immunological Reviews 173, 89–97.CrossRefGoogle ScholarPubMed
Medzhitov, R. & Janeway, C.A. (2002) Decoding the patterns of self and nonself by the innate immune system. Science 296, 298–300.CrossRefGoogle ScholarPubMed
Mosmann, T.R. & Coffman, R.L. (1989) Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Reviews in Immunology 7, 145–173.CrossRefGoogle ScholarPubMed
Richard, M., Grencis, R.K., Humphreys, N.E., Renauld, J.-C. & Van Snick, J. (2000) Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proceedings of the National Academy of Sciences, USA 97, 767–772.CrossRefGoogle ScholarPubMed
Schopf, L.R., Hoffman, K.F., Cheever, A.W., Urban, J.F. Jr & Wynn, T.A. (2002) IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. Journal of Immunology 168, 2383–2392.CrossRefGoogle ScholarPubMed
Shevach, E.M. (2000) Regulatory T cells in autoimmunity. Annual Reviews in Immunology 18, 423–449.CrossRefGoogle Scholar
Siveke, J.T. & Hamann, A. (1998) Cutting edge: T helper 1 and T helper 2 cells respond differentially to chemokines. Journal of Immunology 160, 550–554.CrossRefGoogle Scholar
Stephensen, C.B., Rasooly, R., Jiang, X., Ceddia, M.A., Weaver, C.T., Chandraratna, R.A.S. & Bucy, R.P. (2002) Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. Journal of Immunology 168, 4495–4503.CrossRefGoogle ScholarPubMed
Trinchieri, G. (2001) Regulatory role of T cells producing both interferon G and interleukin 10 in persistent infection. Journal of Experimental Medicine 194,53–57.CrossRefGoogle Scholar
Wakelin, D. (1967) Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–524.CrossRefGoogle ScholarPubMed
Wakelin, D. (1970) The stimulation of immunity and the induction of unresponsiveness to Trichuris muris in various strains of laboratory mice. Zeitschrift für Parasitenkunde 35, 162–168.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975) Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice. Parasitology 71, 51s–60.CrossRefGoogle ScholarPubMed