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Nematocide activity of 6,7-diarylpteridines in three experimental models

Published online by Cambridge University Press:  11 April 2024

C. Ochoa ,
M. Rodríguez ,
L. Domínguez ,
J. Saldaña ,
R. Di Maio ,
P. Alonso-Villalobos  and
M.M. Martínez Grueiro
C. Ochoa*
Affiliation:
Instituto de Química Médica (CSIC), Calle Juan de la Cierva 3, 28006, Madrid, Spain
M. Rodríguez
Affiliation:
Instituto de Química Médica (CSIC), Calle Juan de la Cierva 3, 28006, Madrid, Spain
L. Domínguez
Affiliation:
Facultad de Química, Universidad de la República, Montevideo, Uruguay
J. Saldaña
Affiliation:
Facultad de Química, Universidad de la República, Montevideo, Uruguay
R. Di Maio
Affiliation:
Facultad de Química, Universidad de la República, Montevideo, Uruguay
P. Alonso-Villalobos
Affiliation:
Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, Madrid, Spain
M.M. Martínez Grueiro
Affiliation:
Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, Madrid, Spain
*
*Fax: 91 564 47 53 E-mail: cazmela@iqm.csic.es
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Abstract

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The in vitro nematocide activity of seventeen 6,7-diarylpteridines has been tested using three different experimental models, Caenorhabditis elegans, Nippostrongylus brasiliensis and Heligmosomoides polygyrus. The method of evaluation of inhibition in the secretion of acetylcholinesterase by H. polygyrus seems to be the most indicated to avoid false positives. The in vivo activities, against Trichinella spiralis, of the most in vitro active pteridines have been assayed. All pteridine derivatives bearing 6,7-di-p-bromophenyl substituents have shown in vitronematocide activites in the three experimental models used. Amongst all the pteridines tested in vivo, only 2,4-pteridinedithione derivatives exhibited moderate activity.

Type
Research Article
Information
Journal of Helminthology , Volume 73 , Issue 4 , April 1999 , pp. 333 - 336
Copyright
Copyright © Cambridge University Press 1999

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