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The relevance of in vitro anthelmintic screening tests employing the free-living stages of trichostrongylid nematodes

Published online by Cambridge University Press:  18 November 2009

O.F. Ibarra  and
D.C. Jenkings
O.F. Ibarra
Affiliation:
Dept. of Biochemical Parasitology, The Wellcome Research Laboratories, Beckenham, Kent, BR3 3BS, U.K.
D.C. Jenkings
Affiliation:
Dept. of Biochemical Parasitology, The Wellcome Research Laboratories, Beckenham, Kent, BR3 3BS, U.K.
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Abstract

The response of the free-living stages of Nippostrongylus brasiliensis, Nematospiroides dubius, Haemonchus contortus, Trichostrongylus colubriformis and Ostertagia ostertagi to a wide variety of antiparasitic agents in vitro was investigated.

All the major broad spectrum veterinary anthelmintics showed good activity against each of these worms with EC30 values varying from about 00002mg/1 for certain benzimidazoles and ivermectin to about 6–5 mg/1 for febantel. Of 22 known narrow spectrum anthelmintics useful only against H. contortus and/or helminths other than trichostrongyles, only 10% showed good activity at concentrations equal to or less than 100mg/1. Further, only one of 15 antiprotozoal agents showed good activity in these tests at the 100mg/1 level.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 2 , June 1984 , pp. 107 - 112
Copyright
Copyright © Cambridge University Press 1984

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