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Schistosoma haematobium: the effect of Astiban on the cell composition and ultrastructure of the vitelline gland and the ultrastructure of the tegument and gastrodermis

Published online by Cambridge University Press:  05 June 2009

B. Leitch  and
A. J. Probert
B. Leitch
Affiliation:
School of Biological Sciences, University College, Bangor, Gwynedd, UK
A. J. Probert
Affiliation:
School of Biological Sciences, University College, Bangor, Gwynedd, UK
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Abstract

Treatment of Schistosoma haematobium (Nigerian strain) in hamsters with a single dose of 40 mg/kg of Astiban caused a reduction in the number of S1, S2, and S3 vitelline cells and an increase in S4 cells. Following seven daily doses of the drug, a marked reduction in S1 cells and a complete loss of S2 and S3 cells occurred such that 95% of the cells were S4 cells, all of which were structurally abnormal. Coagulation and disintegration of the protein granules of the vitelline droplets occurred with increase in lipid droplets, swelling of the nuclear membrane and an increase in cytosegresomes. Blebbing of the tegument in both sexes occurred following a single treatment and vacuolation of the basal infolds and alterations to the mitochondria also resulted, but severe erosion of the tegument was rare even following repeated drug treatment. Damage to the gastrodermis was severe with the development of autophagic vacuoles containing whorls of myelin and sequestered portions of damaged tissue. The degree of damage increased with the number of drug treatments.

Keywords

Schistosoma haematobiumvitellariaAstibanultrastructure
Type
Research Note
Information
Journal of Helminthology , Volume 64 , Issue 1 , March 1990 , pp. 65 - 69
Copyright
Copyright © Cambridge University Press 1990

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References

REFERENCES

Bogitsh, B. J. (1975) Cytochemistry of gastrodermal autophagy following starvation in Schistosoma mansoni. Journal of Parasitology, 61, 237–248.CrossRefGoogle ScholarPubMed
Browne, H. G. & Schulert, A. R. (1963) Disposition of Sb124-labelled Astiban R in animals with bilharziasis. Federation Proceedings, 22, 666.Google Scholar
Clarkson, J. (1980) Schistosoma mansoni: studies on the structure of the gut. Ph.D. Thesis, University of Wales.Google Scholar
Clarkson, J. & Erasmus, D. A. (1984) Schistosoma mansoni: an in vivo study of drug induced autophagy in the gastrodermis. Journal of Helminthology, 58, 59–68.CrossRefGoogle Scholar
Erasmus, D. A. (1974) The application of X-ray analysis in the transmission electron microscope to a study of drug distribution in the parasite Schistosoma mansoni (Platyhelminthes). Journal of Microscopy, 102, 59–69.CrossRefGoogle ScholarPubMed
Erasmus, D. A. (1975) Schistosoma mansoni: development of the vitelline cell, its role in drug sequestration and changes induced by Astiban. Experimental Parasitology, 38, 240–256.CrossRefGoogle ScholarPubMed
Erasmus, D. A. (1977) The host-parasite interface of trematodes. In: Advances in Parasitology, 15, 201–242. Academic Press, New York.Google Scholar
Erasmus, D. A. & Popiel, I. (1980) Schistosoma mansoni: drug induced changes in the cell population of the vitelline gland. Experimental Parasitology, 50, 171–187.CrossRefGoogle ScholarPubMed
Khafagy, E. Z. & El-Hawary, M. F. (1974) Effect of Bilharcid and tartar emetic on DNA, RNA and protein synthesis in Escherichia coli B. Biochemical Pharmacology, 23, 1415–1455.CrossRefGoogle ScholarPubMed
Khayyal, M.T. (1964) The effect of antimony uptake on the location and pairing of Schistosoma mansoni. British Journal of Pharmacology and Chemotherapy, 22, 342–348.CrossRefGoogle ScholarPubMed
Leitch, B. & Probert, A. J. (1983) The effect of praziquantel on the ultrastructure of Schistosoma haematobium. Parasitology, 87, lviii.Google Scholar
Leitch, B. & Probert, A. J. (1984) Schistosoma haematobium: Amoscanate and adult worm ultrastructure. Experimental Parasitology, 58, 278–289.CrossRefGoogle ScholarPubMed
Leitch, B., Probert, A. J. & Runham, N. W. (1984) Schistosoma haematobium: the tegumental ultrastructure by scanning and transmission electron microscopy. Parasitology, 89, 71–78.CrossRefGoogle Scholar
Magzoub, M. (1971) Electron microscopy of normal and treated Schistosoma mansoni. Sudan Medical Journal, 9, 178–182.Google Scholar
Molokhia, M. M. & Smith, H. (1968) Antimony uptake by schistosomes. Annals of Tropical Medicine and Parasitology, 62, 158–163.CrossRefGoogle ScholarPubMed
Otubanjo, O. A. (1981) Schistosoma mansoni: Astiban-induced damage to tegument and the male reproductive system. Experimental Parasitology, 52, 161–170.CrossRefGoogle ScholarPubMed
Schulert, A. R., Girgis, N. I., Girgis, G. R., Farid, Z. & McConnell, E. (1967) Comparative anatomy disposition following administration of tartar emetic and sodium antimony dimercaptosuccinate (Astiban R) to hamsters infected with Schistosoma mansoni. East African Medical Journal, 44, 1–8.Google Scholar
Senft, A. W. & Hillman, G. R. (1973) Effect of hycanthone, niridazole and antimony tartrate on schistosome motility. American Journal of Tropical Medicine and Hygiene, 22, 734–742.CrossRefGoogle ScholarPubMed
Shaw, J. R. (1974) In vitro studies on Schistosoma mansoni with special reference to the reproductive biology of the female. Ph.D. Thesis, University of Wales.Google Scholar
Shaw, J. R. & Erasmus, D. A. (1977) Schistosoma mansoni: differential cell death associated with in vitro culture and treatment with Astiban (Roche). Parasitology, 75, 101–109.CrossRefGoogle ScholarPubMed
Standen, O. D. (1953) Experimental schistosomiasis III. Chemotherapy and mode of drug action. Annals of Tropical Medicine and Parasitology, 47, 26–43.CrossRefGoogle ScholarPubMed