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Strongyloidiasis in Latin American immigrants: a pilot study

Published online by Cambridge University Press:  28 April 2016

G. Ostera ,
J. Blum ,
C. Cornejo ,
S. Burgula ,
R. Jeun ,
P.E. Bryan  and
R. Mejia
G. Ostera
Affiliation:
Georgetown University Medical Center, Department of Microbiology and Immunology, Washington, DC, United States of America
J. Blum
Affiliation:
Georgetown University Medical Center, Department of Microbiology and Immunology, Washington, DC, United States of America
C. Cornejo
Affiliation:
Mary's Center, Washington, DC, United States of America
S. Burgula
Affiliation:
Mary's Center, Washington, DC, United States of America
R. Jeun
Affiliation:
Baylor College of Medicine, National School of Tropical Medicine, Houston, Texas, United States of America
P.E. Bryan
Affiliation:
Baylor College of Medicine, National School of Tropical Medicine, Houston, Texas, United States of America
R. Mejia*
Affiliation:
Baylor College of Medicine, National School of Tropical Medicine, Houston, Texas, United States of America
*
*E-mail: rojelio.mejia@bcm.edu
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Abstract

The United States of America (USA) has the largest international population of any nation in the world. Immigrants from Latin American countries, where intestinal parasites are endemic, comprise more than half of this population. This study aims to determine the prevalence of strongyloidiasis, a potentially deadly parasitic infection, in foreign-born individuals. We conducted a cross-sectional study in Washington, DC, to determine the seroprevalence of Strongyloides stercoralis infection using an NIE-ELISA IgG antibody assay. Multi-parallel quantitative real-time polymerase chain reaction (qPCR) was performed in stool samples of NIE-ELISA-positive patients to investigate possible polyparasitism. The NIE-ELISA assay detected an S. stercoralis prevalence of 4.2% in a group of 119 volunteers. Combining NIE-ELISA and qPCR detected a parasite prevalence of 5.0%. Our results underscore the relevance of systematic testing for gastrointestinal parasites in individuals from endemic regions. It also makes a case for a survey in the USA to identify immigrants' risk for strongyloidiasis and other gastrointestinal parasitic infections.

Type
Short Communication
Information
Journal of Helminthology , Volume 91 , Issue 2 , March 2017 , pp. 262 - 266
Copyright
Copyright © Cambridge University Press 2016 

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References

Barcellos, S.H., Goldman, D.P. & Smith, J.P. (2012) Undiagnosed disease, especially diabetes, casts doubt on some of the reported health ‘advantage’ of recent Mexican immigrants. Health Affairs (Millwood) 31, 2727–2737.Google Scholar
Centers for Disease Control and Prevention. (2013) Transmission of Strongyloides stercoralis through transplantation of solid organs. MMWR Morbidity and Mortality Weekly Report 62, 264–266.Google Scholar
Centers for Disease Control and Prevention. (2016) Strongyloides epidemiology and risk factors. Available at http://www.cdc.gov/parasites/strongyloides/epi.html (accessed 12 January 2016).Google Scholar
Ciesielski, S.D., Seed, J.R., Ortiz, J.C. & Metts, J. (1992) Intestinal parasites among North Carolina migrant farmworkers. American Journal of Public Health 82, 1258–1262.Google Scholar
Hauber, H.P., Galle, J., Chiodini, P.L., Rupp, J., Birke, R., Vollmer, E., Zabel, P. & Lange, C. (2005) Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin. Infection 33, 383–386.Google Scholar
Hotez, P.J. (2013) Forgotten people, forgotten diseases: the neglected tropical diseases and their impact on global health and development. 2nd edn. 254 pp. Washington, DC, ASM Press.Google Scholar
Jombo, G.T., Egah, D.Z. & Akosu, J.T. (2007) Intestinal parasitism, potable water availability and methods of sewage disposal in three communities in Benue State, Nigeria: a survey. Annals of African Medicine 6, 17–21.Google Scholar
Mejia, R. & Nutman, T.B. (2012) Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis . Current Opinion in Infectious Diseases 25, 458–463.CrossRefGoogle ScholarPubMed
Mejia, R., Vicuña, Y., Broncano, N., Sandoval, C., Vaca, M., Chico, M., Cooper, P.J. & Nutman, T.B. (2013) A novel, multi-parallel, real-time polymerase chain reaction approach for eight gastrointestinal parasites provides improved diagnostic capabilities to resource-limited at-risk populations. American Journal of Tropical Medicine and Hygiene 88, 1041–1047.Google Scholar
Monge-Maillo, B., López-Vélez, R., Norman, F.F., Ferrere-González, F., Martínez-Pérez, Á. & Pérez-Molina, J.A. (2015) Screening of imported infectious diseases among asymptomatic sub-Saharan African and Latin American immigrants: a public health challenge. American Journal of Tropical Medicine and Hygiene 92, 848–856.Google Scholar
Montes, M., Sawhney, C. & Barros, N. (2010) Strongyloides stercoralis: there but not seen. Current Opinion in Infectious Diseases 23, 500–504.Google Scholar
Nabha, L., Krishnan, S., Ramanathan, R., Mejia, R., Roby, G., Sheikh, V., McAuliffe, I., Nutman, T. & Sereti, I. (2012) Prevalence of Strongyloides stercoralis in an urban US AIDS cohort. Pathogens and Global Health 106, 238–244.Google Scholar
Olsen, A., van Lieshout, L., Marti, H., Polderman, T., Polman, K., Steinmann, P., Stothard, R., Thybo, S., Verweij, J.J. & Magnussen, P. (2009) Strongyloidiasis – the most neglected of the tropical diseases. Transactions of the Royal Society of Tropical Medicine and Hygiene 103, 967–972.Google Scholar
Ostera, G.R., Blum, J.R. & Mejia, R. (2014) Immigrant populations: global health in our backyard. Annals of Global Health 80, 429–432.Google Scholar
Pew Research Center. (2011) Hispanic trends project tabulations of 2011 American community survey. Hispanic population in select U.S. metropolitan areas, 2011. Washington, DC. 2011. Available at http://www.pewhispanic.org/2013/08/29/hispanic-population-in-select-u-s-metropolitan-areas-2011 (accessed 10 July 2015).Google Scholar
Pew Research Center. (2012) Hispanic trends project tabulations of 2012 American community survey. Washington, DC. 2012. Available at http://www.pewhispanic.org/2014/04/29/statistical-portrait-of-the-foreign-born-population-in-the-united-states-2012/#foreign-born-by-state-and-region-of-birth-2012 (accessed 10 July 2015).Google Scholar
Ramanathan, R., Burbelo, P.D., Groot, S., Iadarola, M.J., Neva, F.A. & Nutman, T.B. (2008) A luciferase immunoprecipitation systems assay enhances the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection. Journal of Infectious Diseases 198, 444–451.CrossRefGoogle ScholarPubMed
Rapoport, A.B., McCormick, D. & Cohen, P.A. (2015) Screening for Schistosoma mansoni and Strongyloides stercoralis infection among Brazilian immigrants in the United States. Open Forum Infectious Diseases. doi: 10.1093/ofid/ofv003.Google Scholar
Rascoe, L.N., Price, C., Shin, S.H., McAuliffe, I., Priest, J.W. & Handali, S. (2015) Development of Ss-NIE-1 recombinant antigen based assays for immunodiagnosis of strongyloidiasis. PLOS Neglected Tropical Diseases 9, 1–10.Google Scholar
Schad, G.A. (1989) Morphology and life history of Strongyloides stercoralis . pp. 85–104 in Grove, D.I. (Ed.) Strongyloidiasis a major roundworm infection of man. London, Taylor and Francis.Google Scholar
Schär, F., Trostdorf, U., Giardina, F., Khieu, V., Muth, S., Marti, H., Vounatsou, P. & Odermatt, P. (2013) Strongyloides stercoralis: global distribution and risk factors. PLOS Neglected Tropical Diseases 7, e2288.Google Scholar
Thamwiwat, A., Mejia, R., Nutman, T.B. & Bates, J.T. (2014) Strongyloidiasis as a cause of chronic diarrhea, identified using next-generation Strongyloides stercoralis-specific immunoassays. Current Tropical Medicine Reports 1, 145–147.Google Scholar
Uniform Data System. (UDS) (2014) Mary's Center for Maternal & Child Care. UDS Report, Washington, DC. BHCMIS ID: 037030 (accessed 13 February 2015).Google Scholar
Weatherhead, J.E. & Mejia, R. (2014) Immune response to infection with Strongyloides stercoralis in patients with infection and hyperinfection. Current Tropical Medicine Reports 1, 229–233.CrossRefGoogle Scholar
World Health Organization. (2012) Eliminating soil-transmitted helminthiases as a public health problem in children: Progress Report 2001–2010 and Strategic Plan 2011–2020. Switzerland, World Health Organization Press.Google Scholar