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Vitamin absorption in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats

Published online by Cambridge University Press:  05 June 2009

D. F. Mettrick  and
D. J. Jackson
D. F. Mettrick
Affiliation:
Department of Zoology, University of Toronto, Canada, M5S 1A1
D. J. Jackson
Affiliation:
Department of Zoology, University of Toronto, Canada, M5S 1A1
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Abstract

Uptake and serosal transfer of the vitamins thiamine, riboflavin and folic acid have been studied in vivo in normal and parasitized rats infected with Hymenolepis diminuta (Cestoda).

Regional differences in intestinal uptake of all three vitamins in both uninfected and parasitized animals were not statistically significant.

In the parasitized intestine mucosal uptake and serosal transfer of thiamine were significantly inhibited, with increased mucosal accumulation of the vitamin as luminal thiamine concentration increased.

Apparent increased riboflavin mucosal uptake in parasitized animals, was not matched by the reduced serosal transfer, suggesting adsorption of the vitamin in the unstirred aqueous layers.

Mucosal uptake of folic acid increased in the parasitized gut; serosal transfer and mucosal accumulation were not affected.

These results, indicating vitamin malabsorption associated with infection by H. diminuta, are consistent with the parasite inhibiting mucosal passive transport mechanisms. This conclusion is supported by the changes in net water fluxes associated with vitamin uptake in the parasitized intestine.

Type
Research Papers
Information
Journal of Helminthology , Volume 53 , Issue 3 , September 1979 , pp. 213 - 222
Copyright
Copyright © Cambridge University Press 1979

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