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The anthelmintic activity of a novel organic arsenical, R7/45, upon Brugia pahangi in Meriones unguiculatus

Published online by Cambridge University Press:  05 June 2009

D. A. Denham ,
I. T. C. Midwinter  and
E. A. H. Friedheim
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT, England
I. T. C. Midwinter
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT, England
E. A. H. Friedheim
Affiliation:
The Rockefeller University, 1230, York Avenue, New York 10021–6399, New York, U.S.A.
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Abstract

The new organic arsenical R7/45 is a rapidly acting and very potent anthelmintic against adult Brugia pahangi in jirds. Against adult worms implanted into the peritoneal cavity 5 subcutaneous (SC) injections at 2·5 mg/kg of R7/45 killed 100% of adult worms. A single dose SC of 20 mg/kg was 100% effective and 10 mg/kg 76% effective against adult worms. When jirds were autopsied at different times after treatment at 20 mg/kg SC 89% of worms were dead within three days. R7/45 was not active when given by stomach intubation. Pretreatment of jirds with R7/45 had no effect on adult worms subsequently implanted into jirds. R7/45 was highly active against third and fourth stage larvae of B. pahangi in jirds.

Keywords

Brugia pahangiMeriones unguiculatusR7/47arsenicalschemotherapy
Type
Research Article
Information
Journal of Helminthology , Volume 64 , Issue 2 , June 1990 , pp. 100 - 104
Copyright
Copyright © Cambridge University Press 1990

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References

REFERENCES

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