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The effect of sublethal concentrations of the molluscicide niclosamide on the infectivity of Schistosoma mansoni cercariae*

Published online by Cambridge University Press:  05 June 2009

A. M. Ghandour
A. M. Ghandour
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, St. Albans, Herts
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Abstract

Experiments were conducted to assess the effect of sublethal concentrations of niclosamide on the infectivity of Schistosoma mansoni cercariae. Exposure of cercariae to 0.02 mg/1 and 0.05 mg/1 of niclosamide, respectively, for only two hours increased their mortality during penetration of mammalian host skin. The observed increase in mortality in the skin resulted in a consequent reduction of adult worm recovery from the liver and mesenteric veins of animals infected with the treated cercariae.

Type
Research papers
Information
Journal of Helminthology , Volume 49 , Issue 4 , December 1975 , pp. 245 - 250
Copyright
Copyright © Cambridge University Press 1975

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