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Eosinophilia and the Differential Blood Count in Trichinosis of the Rat

Published online by Cambridge University Press:  05 June 2009

Vernon D. Van Someren
Vernon D. Van Someren
Affiliation:
(Research Student, Department of Parasitology, London School of Hygiene and Tropical Medicine.)
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Extract

The differential blood count of the normal laboratory rat shows at all times a greater proportion of lymphocytes than of neutrophiles. In rats infected with 400–600 larvae there is within 2–4 days of the infection a great relative, and possibly absolute, neutrophilia with a corresponding lymphocytopenia, which becomes less marked as the infection progresses, though the percentage of neutrophiles remains above, and that of lymphocytes below, the normal average. This neutrophilia is accompanied by a moderate left shift in the Cooke polynuclear count which may persist for a considerable period. At the same time the infection is immediately followed by a relative eosinopenia or aneosinophilia which persists for 1–5 days and is probably due to the setting up of a local eosinophilia in the sub-mucosa of the intestine. Thereafter the eosinophilia becomes generalised and reaches its maximum in 7–16 days after infection, with considerable fluctuations from day to day, finally settling to a low-grade eosinophilia which may persist for some months. The degree of eosinophilia appears to be only generally related to the severity of the infection and depends on the individual host animal. Persistence of aneosinophilia is an unfavourable prognostic sign.

Type
Research Article
Information
Journal of Helminthology , Volume 16 , Issue 2 , May 1938 , pp. 83 - 92
Copyright
Copyright © Cambridge University Press 1938

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References

REFERENCES

Augustine, D. L. & Theiler, H, 1932.—“Precipitin and Skin Tests as Aids in diagnosing Trichinosis.” Parasitology. xxiv, 60–86. (W.L. 16035.)CrossRefGoogle Scholar
Brown, T. R., 1898.–“Studies on Trichinosis, with Especial Reference to the Increase of the Eosinophilic Cells in the Blood and Muscle, the Origin of these Cells, and their Diagnostic Importance.” J. exp. Med. iii, 315–347. (W.L. 11189.)CrossRefGoogle Scholar
Conner, L. A., 1929.—“Atypical Forms of Trichinosis.” Ann. intern. Med. iii, 353. (W.L. 1042.)Google Scholar
Donaldson, H. H., 1915.—“The Rat.” Wistar Institute, Philadelphia.Google Scholar
Maass, Z. J., 1933.—“Ueber Eosinophilie im Schweineblut bei Trichinose.” Zbl. Bakt., Abt. 1, Orig. cxxix, (1/2) 29–34. (W.L. 23684.)Google Scholar
Maternowska, I., 1933.—“Intradermale Hautreaktion bei Trichinose.” Zbl. Bakt. Abt. 1, Orig. cxxix (1/2) 284–501. (W.L. 23684.)Google Scholar
McCoy, O. R., 1932–1933.—“Experimental Trichiniasis Infections in Monkeys.” Proc. Sac. exper. Biol. N.Y. xxx, 85–86. (W.L. 16913.)CrossRefGoogle Scholar
Spink, W. W., 1934.—“Effects of Vaccines and Bacterial Parasitic Infections on Eosinophilia in Trichinous Animals.” Arch, intern. Med. Liv, (5), 805–817. (W.L. 1845.)CrossRefGoogle Scholar
Sylvers, I., 1935.—“Observations sur l'hématologie de la trichinellose.” Rev. Microbiol. Saratov., xiv (3) 290–298. (W.L. 22713a.)Google Scholar
Theiler, H., Augustine, D. L. & Spink, W. W., 1935.—“On the Persistence of Eosinophilia and on Immune Reactions in Human Trichinosis several Years after Recovery.” Parasitology, xxvii, 345–354. (W.L. 16035.)CrossRefGoogle Scholar
Wantland, W. W., 1937.—“Blood Studies on Normal and Trichinized White Rabbits.” J. Lab. clin. Med., xxiii, (1), 32–38. (W.L. 11284.)Google Scholar
Weinberg, M. & Séguin, P., 1914.—“Recherchcs biologiques sur l'éosinophile.” Ann. Inst. Pasteur., xxviii, 470–508. (W.L. 857.)Google Scholar