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Nematospiroides dubius in the jird, Meriones unguiculatus: factors affecting the course of a primary infection

Published online by Cambridge University Press:  18 November 2009

John Hannah  and
Jerzy M. Behnke
John Hannah
Affiliation:
Zoology Department, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Jerzy M. Behnke
Affiliation:
Zoology Department, University of Nottingham, University Park, Nottingham NG7 2RD, UK
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Abstract

This project investigated the influence of the age and sex of the host and the level of infection with Nematospiroides dubius on the establishment and duration of a primary infection in the jird. It was found that 30 to 35% fewer worms matured in jirds than in mice and that this proportion was unaffected by the level of infection or by the sex of the host. In contrast the age of the jird was found to be critically important in determining the number of adult worms recovered 14 days after infection. Thus, maximum susceptibility to infection was observed when jirds were 18 to 22 days old. In older jirds susceptibility declined until 30 days after birth and thereafter, when approximately 70% of the infective larvae matured (relative to the number of worms maturing in mice).

The duration of a primary infection in jirds was similar in both sexes but was influenced by the level of infection and by the age of the host at infection. Heavier infections (500 larvae) lasted about 10 days longer than low level infections, and expulsion of the parasite occurred even when the host was infected with only five larvae. The duration of a primary infection was markedly prolonged in neonatal jirds, faecal egg counts remaining positive for 54 to 56 days after infection of 12-day-old jirds.

These results supply some further baseline data for future work on the biology of N. dubius in the jird and they provide support for the involvement of immunological processes in the termination of primary infections of this parasite in mature jirds.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 4 , December 1982 , pp. 329 - 338
Copyright
Copyright © Cambridge University Press 1982

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References

REFERENCES

Behnke, J. M. & Parish, H. A. (1979) Nematospiroides dubius: arrested development of larvae in immune mice. Experimental Parasitology, 47, 116–127.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Wakelin, D. (1977) Nematospiroides dubius: stimulation of acquired immunity in inbred strains of mice. Journal of Helminthohgy, 51, 167–176.CrossRefGoogle ScholarPubMed
Behnke, J. M., Wakelin, D. & Wilson, M. M. (1978) Trichinella spiralis: delayed rejection in mice concurrently infected with Nematospiroidcs dubius. Experimental Parasitology, 46, 121–128.CrossRefGoogle ScholarPubMed
Calkins, C. E. & Stutman, O. (1978) Changes in suppressor mechanisms during postnatal development in mice. Journal of Experimental Medicine, 147, 87–97.CrossRefGoogle ScholarPubMed
Cross, J. H. (1960) The natural resistance of the white rat to Nematospiroides dubius and the effect of cortisone on this resistance. Journal of Parasitology, 46, 175–185.CrossRefGoogle ScholarPubMed
Cross, J. H.(1964) Immunity to Nematospiroides dubius in the Mongolian gerbil. Journal of Parasitology, 50, 25.Google Scholar
Cross, J. H. & Duffy, C. E. (1963) Nematospiroides dubius in the abnormal host. Annals of the New York Academy of Sciences, 113, 88–99.CrossRefGoogle ScholarPubMed
Cross, J. H. & Scott, J. A. (1960) Nematospiroides dubius in the Mongolian gerbil. Journal of Parasitology, 46, 38.Google Scholar
Dineen, J. K. & Kelly, J. D. (1973) Immunological unresponsiveness of neonatal rats to infection with Nippostrongylus brasiliensis: the competence of neonatal lymphoid cells in worm expulsion. Immunology, 25, 141–150.Google ScholarPubMed
Gordon, H. M. & Whitlock, H. V. (1939) A new technique for counting nematode eggs in sheep faeces. Journal of the Council for Scientific and Industrial Research, Australia, 12, 50–52.Google Scholar
Hagan, P. & Wakelin, D. (1982) Nematospiroides dubius: effect of infection on the generation and expression of lymphocytes responses to Trichinella spiralis in mice. Experimental Parasitology. (In press).CrossRefGoogle Scholar
Hannah, J. & Behnke, J. M. (1982) Factors affecting primary and secondary infections of Nematospiroides dubius in the jird, Meriones unguiculatus. Parasitology, 84, xxiii.Google Scholar
Jarrett, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. (1966). Immunological unresponsiveness in adult rats to the nematode Nippostrongylus brasiliensis induced by infection in early life. Nature, 211, 1310–1311.CrossRefGoogle Scholar
Jarrett, E. E., Jarrett, W. F. H. & Urquhart, G. M. (1968) Immunological unresponsiveness to helminth parasites. I. The pattern of Nippostrongylus brasiliensis infections in young rats. Experimental Parasitology, 23, 151–160.CrossRefGoogle ScholarPubMed
Jenkins, D. C. (1977) Nematospiroides dubius: The course of primary and challenge infections in the jird, Meriones unguiculatus. Experimental Parasitology, 41, 335–340.CrossRefGoogle ScholarPubMed
Kassai, T. & Aitken, I. D. (1967) Induction of immunological tolerance in rats to. Nippostrongylus brasiliensis infection. Parasitology, 57, 403–418.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1967) Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. I. The effect of thymectomy, neonatal infections and splenectomy. Parasitology, 57, 335–349.CrossRefGoogle Scholar
Ogilvie, B. M. & Love, R. J. (1974) Cooperation between antibodies and cells in immunity to a nematode parasite. Transplantation Reviews, 19, 147–168.Google ScholarPubMed
Sokal, R. R. & Rohlf, (1969) In: Biometry, p. 240. W. H. Freeman, San Francisco.Google Scholar
Sukhedo, M. V. K. & Groll, N. A. (1981) The location of parasites within their hosts: bile and the site selection behaviour of Nematospiroides dubius. International Journal for Parasitology, 11, 157–162.CrossRefGoogle Scholar