Hostname: page-component-5c6d5d7d68-vt8vv Total loading time: 0.001 Render date: 2024-08-28T14:39:41.989Z Has data issue: false hasContentIssue false

Aetiology of recurrent aphthous ulcers (RAU)

Published online by Cambridge University Press:  29 June 2007

Monir Maurice*
Affiliation:
Head of E.N.T. Section, El-Sahel Teaching Hospital, Ain Shams University.
Wadie Mikhail
Affiliation:
Assist Prof, Faculty of Medicine, Banha University.
Medhat Aziz
Affiliation:
Assist Prof, Biochemistry, Cairo University.
Maged Barsoum
Affiliation:
Prof of Surgery, Cairo University.
*
Dr. Monir Maurice, M.D., E.N.T. Head of E.N.T. Section, El-Sahel Teaching Hospital, Shoubra, Cairo, Egypt.

Abstract

A significant decrease in the pH of saliva has been detected in patients with recurrent aphthous ulcers (RAU). The decreae in pH was more prominent at night than between meals, and some persistent decrease was noticed even after recovery. The total proteins of saliva in RAU were also significantly decreased.

These findings were similar to those observed in patients complaining of petic ulcers, so it is recommended that patients with RAU should be treated with antacids as well as anticholinergic drugs, and that the possibility of concomitant peptic ulceration should also be investigated.

Type
Research Article
Copyright
Copyright © JLO (1984) Limited 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Correll, R. W., Wescott, W. B. and Jensen, J. L. (1981) Recurring, painful oral ulcers. Journal of the American Dental Association, 103: 497498.CrossRefGoogle ScholarPubMed
Ericsson, Y. (1962) Salivary and food factors in dental caries development. International Dental Journal, 12: 476.Google Scholar
Eversole, L. R., Shopper, T. P. and Chambers, D. W. (1982) Effects of suspected foodstuffs challenging agents in the aetiology of recurrent aphthous stomatitis. Oral Surgery, Oral Medicine, Oral Pathology, 54: 3338.CrossRefGoogle ScholarPubMed
Ferguson, M. M., McKay Hart, D., Lindsay, R. and Stephen, K. W. (1978) Progesterone therapy for menstrually related aphthae. International Journal of Oral Surgery, 7: 463470.CrossRefGoogle ScholarPubMed
Fortran, J. S. (1973) The psychosomatic therapy of peptic ulcer. In Sleisenger, M. H. and Fortran, J. S.: Gastrointestinal disease; Pathophysiology, diagnosis, management. Philadelphia, W. B. Saunders Company, p. 163.Google Scholar
Greenspan, J. S., Gadol, N., Olson, J. A. and Talal, N. (1981) Antibody-dependent cellular cytotoxicity in recurrent aphthous ulceration. Clinical and Experimental Immunology, 44: 603610.Google ScholarPubMed
Hooks, J. J. (1978) Possibility of a viral aetiology in recurrent aphthous ulcers and Behcet's syndrome. Journal of Oral Pathology, 7: 353364.CrossRefGoogle ScholarPubMed
Meu Lemans, O. (1960) Chimica Clinica Acta, 5: 757.CrossRefGoogle Scholar
Miller, M. F. and Ship, I. I. (1977) A retrospective study of the prevalence and incidence of recurrent aphthous ulcers in a professional population, 1958–1971. Oral Surgery, Oral Medicine, Oral Pathology, 43: 532537.CrossRefGoogle Scholar
Miller, M. F., Garfunkel, A. A., Ram, C. and Ship, I. I. (1977) Inheritance pattern in recurrent aphthous ulcers: twin and pedigree data. Oral Surgery, Oral Medicine, Oral Pathology, 43: 886891.CrossRefGoogle ScholarPubMed
Moody, F. G. and McGreevy, J. M. (1983) Stomach, Principles of surgery eds: Schwartz, S. I., Shires, G. T., Spencer, F. C., Storer, E. H., McGraw-Hill Book Company, New York, p. 1113.Google Scholar
O'Brien, P. E. (1983) The nature of mucosal defence against ulceration. Peptic ulcer (ed): Carter, D. C. Published by Churchill Livingstone, pp. 28, 43.Google Scholar
O'Brien, T. K., Saunders, D. R. and Templeton, F. E. (1972) Chronic gastric erosions and oral aphthae. American Journal of Digestive Diseases, 17: 447454.CrossRefGoogle ScholarPubMed
Samloff, I. M., Liebman, W. M. and Panitch, N. M. (1975) Serum group I pepsinogen by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology, 69: 83.CrossRefGoogle Scholar
VanHale, H. M., Rogers, R. S. 3d, Doyle, J. A. and Schroeter, A. L. (1981) Immunofiuorescence microscopic studies of recurrent aphthous stomatitis. Archives of Dermatology, 117: 779781.CrossRefGoogle Scholar
Way, L. W. (1983) Stomach and Duodenum. Current surgical diagnosis and treatment, ed. by Way, L. W.L.M.P. Los Altos, California, pp. 437473.Google Scholar
Wray, D., Graykowski, E. A. and Notkins, A. L. (1981) Role of mucosal injury in initiating recurrent aphthous stomatitis. British Medical Journal (Clinical Research) 12; 28315691570.CrossRefGoogle Scholar
Wray, D., Vlagopoulos, T. P. and Siraganian, R. P. (1982) Food allergens and basophil histamine release in recurrent aphthous stomatitis. Oral Surgery, Oral Medicine, Oral Pathology, 54: 388395.CrossRefGoogle ScholarPubMed