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Airway obstruction due to inflammatory myofibroblastic tumour of the posterior pharyngeal wall

Published online by Cambridge University Press:  31 January 2011

H J Theunisse  and
F J A van den Hoogen
H J Theunisse*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Radboud University Nijmegen Medical Centre, The Netherlands
F J A van den Hoogen
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Radboud University Nijmegen Medical Centre, The Netherlands
*
Address for correspondence: Dr H J Theunisse, Department of Otolaryngology and Head and Neck Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands Fax: +31 243540251 E-mail: h.theunisse@kno.umcn.nl
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Abstract

Objective:

We report a unique case of inflammatory myofibroblastic tumour of the posterior wall of the hypopharynx.

Method:

We present the patient's case history, management and histopathological findings. A literature review of all cases localised to the larynx or pharynx is provided and discussed.

Results:

A 67-year-old man presented with airway obstruction due to a spherical mass in the hypopharynx originating from the posterior pharyngeal wall. The tumour was resected. Histopathological examination revealed an inflammatory myofibroblastic tumour. We found only five previously reported cases with pharyngeal localisation. Further treatment of the patient is described.

Conclusion:

Inflammatory myofibroblastic tumour of the pharynx is extremely rare. It is regarded as a neoplastic tumour of intermediate biological potential. In cases with extrapulmonary localisation, the incidence of local recurrence can be as high as 25 per cent. Radical surgery is the treatment of choice; no adjuvant therapy is necessary.

Keywords

MyofibroblastomaPharyngeal NeoplasmsSurgeryPathology
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 6 , June 2011 , pp. 655 - 659
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Coffin, CM, Watterson, J, Priest, JR, Dehner, LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859–72CrossRefGoogle ScholarPubMed
2Wenig, BM, Devaney, K, Bisceglia, M. Inflammatory myofibroblastic tumor of the larynx. A clinicopathologic study of eight cases simulating a malignant spindle cell neoplasm. Cancer 1995;76:2217–293.0.CO;2-N>CrossRefGoogle ScholarPubMed
3Corsi, A, Ciofalo, A, Leonardi, M, Zambetti, G, Bosman, C. Recurrent inflammatory myofibroblastic tumor of the glottis mimicking malignancy. Am J Otolaryngol 1997;18:121–6CrossRefGoogle ScholarPubMed
4Kendall, CH, Johnston, MN. Pseudo-malignant laryngeal nodule (inflammatory myofibroblastic tumour). Histopathology 1998;32:286–7CrossRefGoogle ScholarPubMed
5Martínez, S, Bosch, R, Pardo, J, Salvadó, MT, Alvaro, T. Inflammatory myofibroblastic tumour of larynx. J Laryngol Otol 2001;115:140–2CrossRefGoogle ScholarPubMed
6Ereño, C, López, JI, Grande, J, Santaolalla, F, Bilbao, FJ. Inflammatory myofibroblastic tumour of the larynx. J Laryngol Otol 2001;115:856–8CrossRefGoogle ScholarPubMed
7Guilemany, JM, Alós, L, Alobid, I, Bernal-Sprekelsen, M, Cardesa, A. Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis. Acta Otolaryngol (Stockh) 2005;125:215–19CrossRefGoogle ScholarPubMed
8Alaani, A, Hogg, R, Warfield, A, Olliff, J, Jennings, C. Air bag injury as a cause of inflammatory myofibroblastic pseudotumour of the subglottic larynx progressing to myositis ossificans. Acta Otolaryngol (Stockh) 2005;125:674–7CrossRefGoogle ScholarPubMed
9Rodrigues, M, Taylor, RJ, Sun, CC, Wolf, JS. Inflammatory myofibroblastic tumor of the larynx in a 2-year-old male. ORL J Otorhinolaryngol Relat Spec 2005;67:101–5CrossRefGoogle Scholar
10Suh, S, Seol, H, Lee, J, Lee, Y, Kim, T, Lee, N et al. Inflammatory myofibroblastic tumor of the larynx. Head Neck 2006;28:369–72CrossRefGoogle ScholarPubMed
11Bellezza, G, Cavaliere, A, Del Sordo, R, Sidoni, A. Inflammatory myofibroblastic tumor of the larynx with anaplastic lymphoma kinase (ALK) protein overexpression. A case report. Tumori 2006;92:449–51CrossRefGoogle ScholarPubMed
12Kovach, S, Fischer, A, Katzman, P, Salloum, R, Ettinghausen, S, Madeb, R et al. Inflammatory myofibroblastic tumors. J Surg Oncol 2006;94:385–91CrossRefGoogle ScholarPubMed
13Völker, HU, Scheich, M, Höller, S, Ströbel, P, Hagen, R, Müller-Hermelink, HK et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor – report of two cases with similar morphology. Diagn Pathol 2007;2:1CrossRefGoogle ScholarPubMed
14Zitsch, RP, Pollak, N, Loy, TS. Management of inflammatory pseudotumor of the larynx. Otolaryngol Head Neck Surg 2007;136:139–41CrossRefGoogle ScholarPubMed
15Pooja, B, Bhatia, P, Panda, N, Vasishta, RK. Recurrent inflammatory myofibroblastic tumour of the larynx: a clinicopathologic diagnostic dilemma. J Otolaryngol 2007;36:E24–7CrossRefGoogle ScholarPubMed
16Idrees, MT, Huan, Y, Woo, P, Wang, BY. Inflammatory myofibroblastic tumor of larynx: a benign lesion with variable morphological spectrum. Ann Diagn Pathol 2007;11:433–9CrossRefGoogle ScholarPubMed
17Barreto, DM, Rodrigues, LF, Patrocinio, LG, Coelho, SR, Patrocinio, JA. Inflammatory myofibroblastic tumor in the larynx. Braz J Otorhinolaryngol 2008;74:638CrossRefGoogle ScholarPubMed
18Hartl, T, Moxham, JP, Ludemann, JP, Rassekh, SR. Inflammatory myofibroblastic tumour of the subglottis in a 5-year-old. J Otolaryngol Head Neck Surg 2009;38:E104–6Google Scholar
19Völker, H-U, Scheich, M, Zettl, A, Hagen, R, Müller-Hermelink, HK, Gattenlöhner, S. Laryngeal inflammatory myofibroblastic tumors: different clinical appearance and histomorphologic presentation of one entity. Head Neck 2010;32:1573–8CrossRefGoogle ScholarPubMed
20Pettinato, G, Manivel, JC, De Rosa, N, Dehner, LP. Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol 1990;94:538–46CrossRefGoogle ScholarPubMed
21Coffin, CM, Fletcher, JA. Inflammatory myofibroblastic tumor. In: Fletcher, CDM, Unni, KK, Mertens, F, eds. World Health Organization Classification of Tumours Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press, 2002;91–3Google Scholar
22Gleason, BC, Hornick, JL. Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 2008;61:428–37CrossRefGoogle ScholarPubMed