Hostname: page-component-7479d7b7d-wxhwt Total loading time: 0 Render date: 2024-07-14T19:29:31.191Z Has data issue: false hasContentIssue false
  • English
  • Français

Combined therapy for carcinoma of the nasopharynx: a report of 49 cases

Published online by Cambridge University Press:  29 June 2007

Sheng Hongzheng  and
Jia Haixia
Sheng Hongzheng*
Affiliation:
Shenzhou, China
Jia Haixia
Affiliation:
Shenzhou, China
*
Sheng Hongzheng, Department of Otolaryngology, Futian Hospital, Shenzhen City, Guang DongProvince, 518033, China.
Get access Rights & Permissions [Opens in a new window]

Abstract

From April, 1986 to June 1989 49 Patients (29 male, 20 female) aged 20 to 70 years old whod developed carcinomea of naospharynx (included 15 with relapses) were trated with neoadjuvant regional chemothrapy, followed by radiotherapy, or crysurgery and radiotherapy.

Thirty-three of the patients had squamous cell carcinoma with poor differentiated, four with well differentiated squamous cell carcinoma were included. Tumours were treated with three moalities: (I) Induction regional chemotherapy with temporal aftery catheterization as well as superselective intra-arterial chemotherapy of the femoral artery (chemotherapeutic agents: pingyangmycinum (P), Cisplatin (D), Vomcromstine (V), Methotrexate (M) and P.D.M. programmes); (2)Liquid cryosurgery in 25 cases; (3) Radiotherapy was carried out for two weeks after crysosurgery after chemotherapy.

The date showed CR (complete response—all tumour gone) and PR (partial response—more than 50 percent reduction) in 40 cases (81.6 per cent) and NR (no response—less than 50 per cent or no response) in nine cases (18.3 per cent) following regional chemotherapy. All of the patients were followed up for more than one year, and 48 of them survived (97.9 per cent). Thirty-five cases were followed up over two years and 28 of them survived (80 per cent). Twenty cases were followed up over three years, and 12 of them survived (60 per cent).

The effect of regional chemotherapy and crysurgery in combined treatment for carcinoma of the nasopharynx is discussed in this paper.

Keywords

NasopharynxCarcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 3 , March 1993 , pp. 201 - 204
Copyright
Copyright © JLO (1984) Limited 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ablin, R. J. (1980) Handbook of Cryosurgery, 1st edn.Marcel Dekker, Inc., New York, p 3–12 and 69–79.Google Scholar
Guan, Zhongzheng (1987) Chemotherapy for carcinoma of nasopharynx. In Recent advances in cancer chemotherapy, 1st Edition. (Sen, Yan and Han, Rui, eds.), San Dong Scientific & Technical Publishers, Ji Lan, p 320–325.Google Scholar
Sheng, Hongzheng (1989a) Neoadjuvent regional chemotherapy for head and neck—a report of 80 cases. Chinese Journal of Cancer 8(6): 431.Google Scholar
Sheng, Hongzheng (1989b) The action of cryosurgery in the combination of later malignant tumour of cavity and paranasal sinuses. In Chinese association of refrigeration etc. Advances in cryosurgery, 1st Edition. International Academic Publishers. Beijing: Oxford: New York, p 562–566.Google Scholar