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DNA indices of primary and recurrent squamous cell carcinomas of the tongue and tonsil using image cytometry

Published online by Cambridge University Press:  29 June 2007

S. K. Sarker ,
P. Tierney ,
K. S. Patel ,
C. Fisher  and
D. V. Coleman
S. K. Sarker*
Affiliation:
Cytopathology Unit, St Mary's Hospital Medical School, Imperial College Of Science, Technology and Medicine, University of London, London W2 1NY Academic Surgical Unit, St Mary's Hospital Medical School, Imperial College Of Science, Technology and Medicine, University of London, London W2 1NY Head and Neck Unit, St Mary's Hospital Medical School, Imperial College Of Science, Technology and Medicine, University of London, London W2 1NY
P. Tierney
Affiliation:
The Head and Neck Unit, Royal Marsden Hospital, London SW3 6JJ, UK
K. S. Patel
Affiliation:
Head and Neck Unit, St Mary's Hospital Medical School, Imperial College Of Science, Technology and Medicine, University of London, London W2 1NY The Head and Neck Unit, Royal Marsden Hospital, London SW3 6JJ, UK
C. Fisher
Affiliation:
Histopathology Unit, Royal Marsden Hospital, London SW3 6JJ, UK
D. V. Coleman
Affiliation:
Cytopathology Unit, St Mary's Hospital Medical School, Imperial College Of Science, Technology and Medicine, University of London, London W2 1NY
*
Address for correspondence: S. K. Sarker, Cytopathology and Cytogenetics Unit, Clarence Wing, St Mary's Hospital Medical School, Praed Street, London W2 1NY.
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Abstract

Ploidy status of squamous cell carcinomas of the head and neck (SCCHN) from primary and recurrent tonsillar and tongue lesions has not been compared using image cytometry. We have measured and compared the DNA indices in 41 cases. There were 29 tongue SCCHN, 20/29 were primary and 9/29 were recurrent. Mean DNA index (DI) was 1.19 (range 0.70–1.81) and 1.28 (range 0.79–1.94) respectively. There were 12 tonsillar cases, 10/12 primary and two out of 12 recurrent. Mean DI was 0.84 (range 0.57–1.09) and 1.00 (range 0.98–1.02) respectively. Mean DNA indices of both primary carcinomas were lower than the mean DNA indices of the recurrent carcinomas. This difference between the two groups may be a reflection of their tumour biology. However, since our study is small no definite conclusions can be made at this stage. We aim in the future to evaluate the prognostic role of DNA indices of patients with paired primary and recurrent SCCHN. This may be of clinical value and improve the treatment modalities available to this group.

Keywords

Image cytometryPloidiesHead and neck neoplasmsTongueTonsilCarcinoma, squamous cell
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 3 , March 1996 , pp. 237 - 239
Copyright
Copyright © JLO (1984) Limited 1996

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