Hostname: page-component-77c89778f8-n9wrp Total loading time: 0 Render date: 2024-07-19T14:22:58.494Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of thiocolchicoside, a commonly used myorelaxant, on the acoustic reflex

Published online by Cambridge University Press:  02 March 2017

H H Arslan ,
S Cebeci ,
U Yildizoglu ,
S Pusat  and
F Yavuz
H H Arslan
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
S Cebeci*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Zübeyde Hanım Maternity Hospital, Etlik, Ankara, Turkey
U Yildizoglu
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, Beytepe Military Hospital, Cankaya, Ankara, Turkey
S Pusat
Affiliation:
Department of Neurosurgery, Etimesgut Military Hospital, Yenimahalle, Ankara, Turkey
F Yavuz
Affiliation:
Department of Physical Therapy and Rehabilitation, Etimesgut Military Hospital, Yenimahalle, Ankara, Turkey
*
Address for correspondence: Dr Suleyman Cebeci, Serhat Mahallesi, 1292 Sokak, No: 5/B/30 Yenimahalle, Ankara 06374, Turkey Fax: 00 90 312 323 8191 E-mail: drscebeci@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To determine whether thiocolchicoside, a commonly used myorelaxant, may impair the acoustic reflex.

Methods:

Forty-two patients scheduled to receive thiocolchicoside treatment for different reasons were enrolled in the study. Acoustic reflex thresholds at 500, 1000, 2000 and 4000 Hz were determined and analysed statistically pre-treatment and on the 5th day of treatment.

Results:

Increases were observed in the mean acoustic reflex thresholds on the 5th day of treatment compared to pre-treatment, at all frequencies, except right contralateral thresholds at 500 and 2000 Hz. These increases were statistically significant for right ipsilateral thresholds at 2000 and 4000 Hz, left ipsilateral thresholds at 500, 1000, 2000 and 4000 Hz, and left contralateral thresholds at 2000 and 4000 Hz (p ≤ 0.05), but not at other frequencies (p > 0.05).

Conclusion:

Muscle relaxant drugs, especially those affecting the central nervous system, may weaken the stapedial muscle so that the ability of noise to cause acoustic trauma may become evident. For this reason, physicians should advise their patients to avoid loud noises when muscle relaxant therapy is prescribed.

Keywords

ReflexAcousticAcoustic TraumaCentrally Acting Muscle Relaxants
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 6 , June 2017 , pp. 497 - 500
Copyright
Copyright © JLO (1984) Limited 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented as a poster at the 11th International Congress of Otorhinolaryngology and Head and Neck Surgery, 17–19 April 2014, Ankara, Turkey.

References

1 Akyıldız, N, ed. Diseases and Microsurgery of Ear, volume 1 [in Turkish] Ankara: Bilimsel Tıp Yayınevi, 1998 Google Scholar
2 Akyıldız, N, ed. Diseases and Microsurgery of Ear, volume 2 [in Turkish] Ankara: Bilimsel Tıp Yayınevi, 1998 Google Scholar
3 Şahin, F. Effects of ethyl alcohol on acoustic reflex and trauma [in Turkish] Fırat Tıp Dergisi 2010;15:79–82 Google Scholar
4 Artusi, M, Nicoli, S, Colombo, P, Bettini, R, Sacchi, A, Santi, P. Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro. J Pharm Sci 2004;93:2431–8CrossRefGoogle ScholarPubMed
5 Patat, A, Klein, MJ. Effects of acute and repeated doses of two muscle relaxants chlormezanone and thiocolchicoside, on vigilance and psychomotor performance of healthy volunteers. Hum Psychopharmacol Clin Exp 1991;6:285–92CrossRefGoogle Scholar
6 Janbroers, JM. Review of the toxicology, pharmacodynamics and pharmacokinetics of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions. Acta Ther 1987;13:221–7Google Scholar
7 Borg, E, Moller, A. Effect of central depressants on the acoustic middle ear reflex in rabbit. A method for quantitative measurements of drug effect on the CNS. Acta Physiol Scand 1975;94:327–38Google Scholar
8 Robinette, MS, Alper, RR, Brey, HR. The effect of alcohol on the acoustic Reflex Relaxation Index. J Aud Res 1981;21:159–65Google Scholar
9 Venet, T, Rumeau, C, Campo, P, Rieger, B, Thomas, A, Cour, C. Neuronal circuits involved in the middle-ear acoustic reflex. Toxicol Sci 2011;119:146–55CrossRefGoogle ScholarPubMed
10 Borg, E, Moller, AR. Effect of ethyl alcohol and pentobarbital sodium on the acoustic middle ear reflex in man. Acta Otolaryngol 1967;64:415–26Google Scholar
11 Cohill, EN, Greenberg, HJ. Effects of ethyl alcohol on the acoustic reflex threshold. J Am Audiol Soc 1977;2:121–3Google Scholar
12 Robinette, MS, Brey, RH. Influence of alcohol on the acoustic reflex and temporary threshold shift. Arch Otolaryngol 1978;104:31–7Google Scholar
13 Ozturk, M, Ila, K, Erdogan, S, Polat, A, Topdag, M. The effect of alprazolam on acoustic stapedius reflex thresholds in healthy volunteers. Indian J Otolaryngol Head Neck Surg 2014;66:347–51Google Scholar
14 Farkas, Z. Acoustic reflex and general anaesthesia. Scand Audiol Suppl 1983;17:43–6Google Scholar
15 Ciardo, A, Garavello, W, Leva, M, Graziano, B, Gaini, RM. Reversed ipsilateral acoustic reflex: a study on subjects treated with muscle relaxants. Ear Hear 2005;26:96–103 CrossRefGoogle Scholar
16 Ruth, RA, Arora, NS, Gal, TJ. Stapedius reflex in curarized subjects: an index of neuromuscular weakness. J Appl Physiol Respir Environ Exerc Physiol 1982;52:416–20Google Scholar
17 Kemaloğlu, YK, Tutar, H. Noise induced hearing loss and acoustic trauma [in Turkish]. Turkiye Klinikleri J ENT - Special Topics 2013;6:44–54 Google Scholar
18 Campo, P, Venet, T, Thomas, A, Cour, C, Castel, B, Nunge, H et al. Inhaled toluene can modulate the effects of anesthetics on the middle-ear acoustic reflex. Neurotoxicol Teratol 2013;35:1–6 Google Scholar
19 Yamane, M, Nomura, Y. Analysis of stapedial reflex in neuromuscular diseases. ORL J Otorhinolaryngol Relat Spec 1984;46:84–96 CrossRefGoogle ScholarPubMed
20 Shimizu, T, Hayashida, T, Hayashi, H, Kato, S, Tanabe, H. Stapedial reflex in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 1996;60:544–8Google Scholar