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Hualuronic acid in secretory otitis media

A biochemical study of mucoid middle-ear effusions and serum

Published online by Cambridge University Press:  29 June 2007

C. Laurent ,
A. Tengblad  and
Anna Engströ-Laurent
C. Laurent*
Affiliation:
The Department of Otorhinolaryngology, Central Hospital of Falun, Falun, Sweden
A. Tengblad
Affiliation:
The Department of Medical and Physiological Chemistry, University of Uppsala, Uppsala, Sweden.
Anna Engströ-Laurent
Affiliation:
The Department of Medical and Physiological Chemistry, University of Uppsala, Uppsala, Sweden.
*
Claude Laurent, MD, Department of Otorhinolaryngology, Central Hospital, S—791 82, Falun, Sweden.
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Summary

Middle-ear effusions of the mucoid type were collected from 14 children with secretory otitis media and analysed by a sensitive assay for hyaluronic acid. The concentration of the polysaccharide varied between three and 42 μg/g. in different patients but was in the same range in effusion material taken from the two ears of the same patient. As the hyaluronic acid concentrations were high compared to the serum levels, the results indicate that the effusion material contains a component derived from connective tissue.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 2 , February 1986 , pp. 135 - 140
Copyright
Copyright © JLO (1984) Limited 1986

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