Hostname: page-component-5c6d5d7d68-wtssw Total loading time: 0 Render date: 2024-08-17T22:18:36.388Z Has data issue: false hasContentIssue false
  • English
  • Français

Internal jugular vein thrombosis in association with the factor V Leiden mutation

Published online by Cambridge University Press:  29 June 2007

P. Arullendran ,
P. Jani ,
T. Baglin  and
D. A. Moffat
P. Arullendran*
Affiliation:
Departments of Otolaryngology, Addenbrookes Hospital, Cambridge.
P. Jani
Affiliation:
Departments of Otolaryngology, Addenbrookes Hospital, Cambridge.
T. Baglin
Affiliation:
Departments of Haematology, Addenbrookes Hospital, Cambridge.
D. A. Moffat
Affiliation:
Departments of Otolaryngology, Addenbrookes Hospital, Cambridge.
*
Address for correspondence: Mr P. Arullendran, Specialist Registrar, ENT Department, Sunderland Royal Hospital, Sunderland SR4 7TP.
Get access Rights & Permissions [Opens in a new window]

Abstract

We report an unusual case of internal jugular vein thrombosis in a 57-year-old female, with the recently discovered factor V Leiden (FVR506Q) mutation. The molecular basis of this mutation is described, and the importance of screening for hereditary venous thrombotic states is emphasized.

Keywords

Jugular veinsThrombosis, venousFactor V
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 4 , April 1998 , pp. 383 - 386
Copyright
Copyright © JLO (1984) Limited 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beauchamp, N., Daly, M., Hampton, K., Cooper, P., Preston, F., Peake, I. (1994) High prevalence of a mutation in the factor V gene within the UK population: Relationship to activated protein C resistance and familial thrombosis. British Journal of Haematology 88: 219–222.Google Scholar
Bertina, R., Koeleman, B., Koster, T., Rosendaal, F., Dirven, R., de Ronde, H., van der Velden, P., Reitsma, P. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369: 64–67.Google Scholar
Dahlback, B., Carlsson, M., Svensson, P. (1993) Familial thrombophilia due to unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C: Leiden thrombophilia study. Proceedings of the National Academy of Sciences of the United States of America 90: 1004–1008.Google Scholar
Horstkamp, B., Lubke, M., Kentenich, H., Reiss, H., Buscher, U., Lichtenegger, W. (1996) Internal jugular vein thrombosis caused by resistance to activated protein C as a compilation of ovarian hyperstimulation after in vitro fertilization. Human Reproduction 11(2): 280–282.Google Scholar
Jorquera, J., Montoro, J., Fernandez, M., Azaner, J. A., Azaner, J. (1994) Modified test for activated protein C resistance. Lancet 344: 1162–1163.CrossRefGoogle ScholarPubMed
Rosendaal, F., Koster, T., Vandenbrouck, J., Reitsma, P. (1995) High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 85: 1504–1508.Google Scholar
Wilde, J. T. (1995) The investigation of a patient with unexpected venous thrombosis. Postgraduate Medical Journal 71: 720–724.CrossRefGoogle ScholarPubMed