Hostname: page-component-77c89778f8-m8s7h Total loading time: 0 Render date: 2024-07-20T08:29:38.206Z Has data issue: false hasContentIssue false
  • English
  • Français

Middle-ear carcinoid tumour metastasising to the parapharyngeal space and the parotid gland

Published online by Cambridge University Press:  31 January 2022

M P Sato Open the ORCID record for M P Sato [Opens in a new window] ,
N Otsuki ,
S Iwamoto  and
K Doi
M P Sato*
Affiliation:
Department of Otorhinolaryngology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan
N Otsuki
Affiliation:
Department of Otorhinolaryngology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan
S Iwamoto
Affiliation:
Department of Otorhinolaryngology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan
K Doi
Affiliation:
Department of Otorhinolaryngology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan
*
Author for correspondence: Dr Mitsuo P Sato, Department of Otorhinolaryngology, Kindai University Faculty of Medicine, Ohno-higashi 377-2, Osakasayama, Osaka 589-8511, Japan E-mail: qqd755pd@spice.ocn.ne.jp Fax: +81 72 366 0206
Get access Rights & Permissions [Opens in a new window]

Abstract

Background. Middle-ear carcinoid tumour is a rare malignant tumour with an indolent course occasionally causing regional or distant metastasis. This paper presents a case of middle-ear carcinoid tumour metastasising to the parapharyngeal space and the parotid gland 20 years after the first surgery.

Case report. A 35-year-old woman who underwent multiple tympanomastoidectomies for middle-ear carcinoid presented with tumours of both the parapharyngeal space and parotid gland, detected by regular imaging. Based on the clinical course, metastatic relapse of middle-ear carcinoid was suspected. This was treated with subtotal parotidectomy with elective neck dissection (levels II and III), leading to the pathological diagnosis of carcinoid tumour. A cervico-parotid approach was selected to avoid complications associated with parapharyngeal space tumour removal. Transient facial palsy (House–Brackmann grade III) occurred, which completely recovered two months after surgery.

Conclusion. Awareness of parapharyngeal space tumours possibly caused by metastasis from a middle-ear tumour is necessary.

Keywords

Carcinoid TumorMiddle EarNeck DissectionParapharyngeal SpaceParotid Gland
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 1 , January 2023 , pp. 112 - 116
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr M Sato takes responsibility for the integrity of the content of the paper

References

Sahan, M, Yildirim, N, Arslanoğlu, A, Karslioğlu, Y, Kazikdasş, KC. Carcinoid tumor of the middle ear: report of a case. Am J Otolaryngol 2008;29:352–6CrossRefGoogle ScholarPubMed
Fundakowski, CE, Chapman, JR, Thomas, G. Middle ear carcinoid with distant osseous metastasis. Laryngoscope 2013;123:779–82CrossRefGoogle ScholarPubMed
Salzman, R, Stárek, I, Tichá, V, Skálová, A, Kučera, J. Metastasizing middle ear carcinoid: an unusual case report, with focus on ultrastructural and immunohistochemical findings. Otol Neurotol 2012;33:1418–21CrossRefGoogle ScholarPubMed
Liu, G, Chen, F, Li, JN, Liu, SX. Carcinoid tumor of the middle ear: a case report and review of literature. Int J Clin Exp Pathol 2014;7:7105–9Google ScholarPubMed
Riffat, F, Dwivedi, RC, Palme, C, Fish, B, Jani, P. A systematic review of 1143 parapharyngeal space tumors reported over 20 years. Oral Oncol 2014;50:421–30CrossRefGoogle ScholarPubMed
López, F, Suárez, C, Vander Poorten, V, Mäkitie, A, Nixon, IJ, Strojan, P et al. Contemporary management of primary parapharyngeal space tumors. Head Neck 2019;41:522–35Google ScholarPubMed
Teshima, M, Otsuki, N, Shinomiya, H, Morita, N, Furukawa, T, Morimoto, K et al. Impact of retropharyngeal lymph node dissection in the surgical treatment of hypopharyngeal cancer. Head Neck 2019;41:1738–44CrossRefGoogle ScholarPubMed
Otsuki, N, Nishikawa, T, Iwae, S, Saito, M, Mohri, M, Nibu, K. Retropharyngeal node metastasis from papillary thyroid carcinoma. Head Neck 2007;29:508–11CrossRefGoogle ScholarPubMed
Batsakis, JG, Sneige, N. Parapharyngeal and retropharyngeal space diseases. Ann Otol Rhinol Laryngol 1989;98:320–1CrossRefGoogle ScholarPubMed
Prasad, SC, Piccirillo, E, Chovanec, M, La Melia, C, De Donato, G, Sanna, M. Lateral skull base approaches in the management of benign parapharyngeal space tumors. Auris Nasus Larynx 2015;42:189–98CrossRefGoogle ScholarPubMed
Sato, MP, Saito, K, Fujita, T, Seo, T, Doi, K. Primary liposarcoma with cholesteatoma in mastoid. J Int Adv Otol 2020;16:134–7CrossRefGoogle ScholarPubMed
Torske, KR, Thompson, LD. Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol 2002;15:543–55CrossRefGoogle ScholarPubMed
Pellini, R, Ruggieri, M, Pichi, B, Covello, R, Danesi, G, Spriano, G. A case of cervical metastases from temporal bone carcinoid. Head Neck 2005;27:644–7CrossRefGoogle ScholarPubMed
Knerer, B, Matula, C, Youssefzadeh, S, Ulrich, W, Swoboda, H. Treatment of a local recurrence of a carcinoid tumor of the middle ear by extended subtotal petrosectomy. Eur Arch Otorhinolaryngol 1998;255:57–61CrossRefGoogle ScholarPubMed
Ramsey, MJ, Nadol, JB Jr, Pilch, BZ, McKenna, MJ. Carcinoid tumor of the middle ear: clinical features, recurrences, and metastases. Laryngoscope 2005;115:1660–6CrossRefGoogle ScholarPubMed
Aslan, DL, Gulbahce, HE, Pambuccian, SE, Manivel, JC, Jessurun, J. Ki-67 immunoreactivity in the differential diagnosis of pulmonary neuroendocrine neoplasms in specimens with extensive crush artifact. Am J Clin Pathol 2005;123:874–8CrossRefGoogle ScholarPubMed
Aoki, M, Mizuta, K, Ueda, N, Yamada, N, Ito, Y, Kato, H et al. Surgical treatment by partial petrosectomy for a middle-ear carcinoid with progressive extension: a case report and review of the literature. Int J Otolaryngol 2010;2010:818673CrossRefGoogle ScholarPubMed
Warth, A, Herpel, E, Krysa, S, Hoffmann, H, Schnabel, PA, Schirmacher, P et al. Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential. Exp Mol Med 2009;41:349–53CrossRefGoogle Scholar
Kim, HS, Yi, SY, Jun, HJ, Ahn, JS, Ahn, MJ, Lee, J et al. L1 cell adhesion molecule as a predictor for recurrence in pulmonary carcinoids and large-cell neuroendocrine tumors. APMIS 2009;117:140–6CrossRefGoogle ScholarPubMed