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Plasmablastic lymphoma of the larynx: report of two cases

Published online by Cambridge University Press:  19 September 2012

K Stephenson ,
S Peer ,
D Govender  and
J J Fagan
K Stephenson*
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
S Peer
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
D Govender
Affiliation:
Division of Anatomical Pathology, University of Cape Town, South Africa
J J Fagan
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
*
Address for correspondence: Dr Kate Stephenson, Division of Otorhinolaryngology, University of Cape Town, H-53 Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa E-mail: katestephenson@doctors.org.uk
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Abstract

Objective:

To report two cases of laryngeal plasmablastic lymphoma, a rare and relatively recently described form of non-Hodgkin's lymphoma. It has not previously been described in the larynx, nor associated with upper airway obstruction.

Case reports:

We describe the clinicopathological features of two such cases in human immunodeficiency virus positive patients, and we discuss their unusual presentations and diagnostic features.

Conclusion:

When evaluating a laryngeal tumour, plasmablastic lymphoma and other non-Hodgkin's lymphomata should be considered as differential diagnoses, particularly in the setting of a high prevalence of human immunodeficiency virus infection. Biopsy with detailed histopathological and immunohistochemical evaluation is recommended to ensure correct diagnosis and optimal management.

Keywords

LarynxPlasmablastic LymphomaLymphoma, Non-Hodgkin'sLymphoma, B-CellHuman Immunodeficiency Virus
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 96 - 99
Copyright
Copyright © JLO (1984) Limited 2012

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