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Skin reactivity to vasomotor agents in non-eosinophilic and eosinophilic non-allergic rhinitis

Published online by Cambridge University Press:  08 March 2006

Dušanka Milošević ,
Ljiljana Janošević ,
Slobodanka Janošević ,
Zoran Invanković  and
Ranko Dergenc
Dušanka Milošević
Affiliation:
Clinic of Otorhinolaryngology, Clinical Centre ’Zvezdara’, Belgrade, Yugoslavia.
Ljiljana Janošević
Affiliation:
Institute of Otorhinolaryngology and Maxillofacial Surgery, University Clinical Centre of Serbia, Belgrade, Yugoslavia.
Slobodanka Janošević
Affiliation:
Institute of Social Medicine, Statistics and Health Investigations[dagger], University School of Medicine, Belgrade, Yugoslavia.
Zoran Invanković
Affiliation:
Clinic of Otorhinolaryngology, Clinical Centre ’Zvezdara’, Belgrade, Yugoslavia.
Ranko Dergenc
Affiliation:
Clinic of Otorhinolaryngology, Clinical Centre ’Zvezdara’, Belgrade, Yugoslavia.
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Abstract

The aim of this prospective study was to examine skin reactivity to four vasomotor agents and to determine whether non-eosinophilic rhinitis patients differ from patients with eosinophilic rhinitis. Nasal cytology enabled us to classify 74 rhinitis patients into a non-eosinophilic (n = 63) and an eosinophilic group (n = 11). Skin reactivity to intradermal tests with papaverine, metacholine, histamine and compound 48/80 was measured. No significant difference for papaverine, metacholine, histamine and compound 48/80, singly, was found between the non-eosinophilic and eosinophilic group. The frequency of the total pathological skin reactivity to vasomotor agents, singly and in combinations, was greater in the eosinophilic (91 per cent) then in the non-eosinophilic group (78 per cent) but intergroup difference was not significant. These findings suggest that pathologic skin reactivity to vasomotor agents is a feature of non-eosinophilic as well as eosinophilic non-allergic rhinitis patients and indicate that no difference is noticed in the skin reactivity between these groups.

Keywords

Skin Tests RhinitisVasomotor SystemDrug Effects
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 116 , Issue 7 , July 2002 , pp. 519 - 522
Copyright
© Royal Society of Medicine Press Limited 2002

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