Hostname: page-component-77c89778f8-swr86 Total loading time: 0 Render date: 2024-07-19T18:18:44.802Z Has data issue: false hasContentIssue false
  • English
  • Français

Thyroid involvement by laryngeal cancer among Iranian patients

Published online by Cambridge University Press:  27 March 2013

B Naghibzadeh ,
E Razmpa ,
N Amiri ,
GH Naghibzadeh  and
F Bandarian
B Naghibzadeh
Affiliation:
Department of Otolaryngology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
E Razmpa*
Affiliation:
Department of Otolaryngology, Tehran University of Medical Sciences, Tehran, Iran
N Amiri
Affiliation:
Department of Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
GH Naghibzadeh
Affiliation:
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
F Bandarian
Affiliation:
Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farzan Clinical Research Institute, Tehran, Iran
*
Address for correspondence: Dr Ebrahim Razmpa, PO Box 13185-1678, Tehran, Iran Fax: +9821 66423304 E-mail: swt_f@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Asian patients with laryngeal cancer have been reported to have a high prevalence of thyroid involvement. This study aimed to investigate the prevalence of thyroid invasion in Iranian patients with laryngeal cancer.

Methods:

Hospital records for all patients with a definite diagnosis of laryngeal cancer between 1996 and 2009 (351 patients) were reviewed, and the prevalence of thyroid invasion was established based on the pathology report at the time of surgery.

Results:

Thyroid invasion was found in 16 patients (4.55 percent), and was limited to one thyroid lobe in two-thirds of cases. All instances of thyroid invasion occurred in patients with stage III (81.25 percent) or IV (18.75 percent) cancer. No case of metastasis was reported. The glottic region was identified as the tumour origin in most cases of thyroid invasion (56.25 percent).

Conclusion:

Most cases of thyroid invasion by laryngeal cancer occurred in cancer stage III, at grades G1 and G2, among male patients, and arose from tumours of the glottic region.

Keywords

Laryngeal NeoplasmsCarcinomaIranThyroidPathologyNeoplasm GradingNeoplasm Staging
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 5 , May 2013 , pp. 501 - 504
Copyright
Copyright © JLO (1984) Limited 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Gal, RL, Gal, TJ, Klotch, DW, Cantor, AB. Risk factors associated with hypothyroidism after laryngectomy. Otolaryngol Head Neck Surg 2000;123:211–17CrossRefGoogle ScholarPubMed
2Brennan, JA, Meyers, AD, Jafek, BW. The intraoperative management of the thyroid gland during laryngectomy. Laryngoscope 1991;101:929–34CrossRefGoogle ScholarPubMed
3McKenna, JP, Fornataro-Clerici, LM, McMenamin, PG, Leonard, RJ. Laryngeal cancer: diagnosis, treatment and speech rehabilitation. Am Fam Physician 1991;44:123–9Google ScholarPubMed
4Chu, EA, Kim, YJ. Laryngeal cancer: diagnosis and preoperative work-up. Otolaryngol Clin North Am 2008;41:673–95CrossRefGoogle ScholarPubMed
5Croce, A, Moretti, A, Bianchedi, M. Thyroid gland involvement in cancer of the larynx [in Italian]. Acta Otorhinolaryngol Ital 1991;11:429–35Google ScholarPubMed
6Yuen, AP, Wei, WI, Lam, KH, Ho, CM. Thyroidectomy during laryngectomy for advanced laryngeal carcinoma – whole organ section study with long-term functional evaluation. Clin Otolaryngol Allied Sci 1995;20:145–9CrossRefGoogle ScholarPubMed
7Harrison, DFN. Laryngectomy for subglottic lesions. Laryngoscope 1975;85:1208–10CrossRefGoogle ScholarPubMed
8Tucker, G Jr.Some clinical inferences from the study of serial laryngeal sections. Laryngoscope 1963;73:728–48CrossRefGoogle Scholar
9Welsh, LW. The normal human laryngeal lymphatics. Ann Otol Rhinol Laryngol 1964;73:569–82CrossRefGoogle ScholarPubMed
10Sano, H, Hamashima, C. Comparison of laryngeal cancer mortality in five countries: France, Italy, Japan, UK and USA from the WHO mortality database (1960–2000). Jpn J Clin Oncol 2005;35:626–9CrossRefGoogle ScholarPubMed
11Bosetti, C, Garavello, W, Levi, F, Lucchini, F, Negri, E, La Vecchia, C. Trends in laryngeal cancer mortality in Europe. Int J Cancer 2006;119:673–81CrossRefGoogle ScholarPubMed
12Biel, MA, Maisel, RH. Indications for performing hemithyroidectomy for tumors requiring total laryngectomy. Am J Surg 1985;150:435–9CrossRefGoogle ScholarPubMed
13Croce, A, Moretti, A, Bianchedi, M, Boccia, MM, de Vincentiis, M. Thyroid gland and carcinoma of the hypopharyngeal-laryngeal region [in Italian]. G Chir 1991;12:489–92Google ScholarPubMed
14Gilbert, RW, Cullen, RJ, van Nostrand, AW, Bryce, DP, Harwood, AR. Prognostic significance of thyroid gland involvement in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 1986;112:856–9CrossRefGoogle ScholarPubMed
15Thawley, SE. Cysts and tumors of the larynx. In: Paparella, MM, Shumrick, DA, Gluckman, JL, Meyerhoff, WL, eds. Otolaryngology (Head and Neck), 3rd edn.Philadelphia: W B Saunders, 1991;3:2314–59Google Scholar
16Smolarz, K, Malke, G, Voth, E, Scheidhauer, K, Eckel, HE, Jungehülsing, M et al. Hypothyroidism after therapy for larynx and pharynx carcinoma. Thyroid 2000;10:425–9CrossRefGoogle ScholarPubMed