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Treatment of perennial allergic rhinitis by sodium cromoglycate plus 0.025 per cent xylometazoline

(a double-blind study)

Published online by Cambridge University Press:  29 June 2007

M. Fradis ,
L. Podoshin  and
R. Gertner
M. Fradis
Affiliation:
Haifa, Israel
L. Podoshin*
Affiliation:
Haifa, Israel
R. Gertner
Affiliation:
Haifa, Israel
*
Professor L. Podoshin, M.D., Haifa Medical Center (Rothschild), Department of Otolaryngology, P.O. Box 4940, Haifa 31 048, Israel.
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Summary

The object of this double-blind study was to assess the therapeutic effects of a combination of two per cent sodium cromoglycate and 0.025 per cent xylometazoline compared with a matched placebo. Forty patients were included in the two-week study.

The treatment was found to be rapidly effective taking only a day to control symptoms in almost 80 per cent of the patients in the group receiving active treatment.

No evidence of rebound effects due to the decongestant was observed during the study.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 7 , July 1987 , pp. 666 - 672
Copyright
Copyright © JLO (1984) Limited 1987

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References

Bende, M., Andersson, K. E., Johannsson, C-J.Sjogren, G. and Svensson, G. (1984) Dose response relationship of a topical nasal decongestant: phenylpropanolamine. Acta Otolaryngologica, 98: 543–547.CrossRefGoogle ScholarPubMed
Frostad, A. B. (1977) The treatment of seasonal allergic rhinitis with 2% aqueous solution of sodium cromoglycate delivered by a metered dose nasal spray. Clinical Allergy, 7: 347–353.CrossRefGoogle ScholarPubMed
Gertner, R., Podoshin, L. and Fradis, M. (1984) A simple method of measuring the nasal airway in clinical work. Journal of Laryngology and Otology, 48: 351–355.CrossRefGoogle Scholar
Hamilton, L. H. (1981) Effect of xylometasoline nasal spray on nasal conductance in subjects with coryza. Journal of Otolaryngology, 10(2): 109–116.Google Scholar
Kluger, H. A. (1959) Beitrag zur behandlung akuter und rezidivierender schwellingszustande der vasenschleimhaut. Medizinische Welt, 40: 1875–1878.Google Scholar
Konno, A., Togawa, K. and Nishihira, Sh. (1982) Participation of vascular reflex in mucosal swelling in nasal allergy. Acta Otolaryngologica, 94: 131–140.CrossRefGoogle ScholarPubMed
Lobaton, P., Seranno, V., Rubio, N. and Gomerz, D. (1975) Treatment of perennial rhinitis with 2% solution of sodium cromoglycate, Rhinology, 13: 91–97.Google ScholarPubMed
Mygind, N. (1973) Local effect of intra-nasal beclomethasone dipropionate aerosol in hay fever. British Medical Journal, i: 464–469.CrossRefGoogle Scholar
Petruson, B. (1981) Treatment with xylometazoline (Otrivin) nosedrops over a six week period. Rhinology, 19: 167–172.Google Scholar
Wihl, J. A. (1979) Immunotherapy indications and contraindications. Acta Otolaryngologica, Supplement, 360: 12–20.Google Scholar