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Case report of Zenker's diverticulum in identical twins: further evidence for genetic predisposition

Published online by Cambridge University Press:  11 January 2010

T Klockars*
Affiliation:
Department of Otorhinolaryngology – Head & Neck Surgery, Helsinki University Central Hospital, Finland
A Mäkitie
Affiliation:
Department of Otorhinolaryngology – Head & Neck Surgery, Helsinki University Central Hospital, Finland
*
Address for correspondence: Dr Tuomas Klockars, Department of Otorhinolaryngology – Head & Neck Surgery, Helsinki University Central Hospital, PL 220, FIN-00029 HUS, Finland. Fax:+358 9 471 750 22 E-mail: tuomas.klockars@fimnet.fi

Abstract

Objective:

We report identical twins with Zenker's diverticulum.

Methods:

Case report and literature review.

Conclusions:

Geographical and racial variation in occurrence, and rare familial cases, suggest that inherited factors play a role in the pathogenesis of Zenker's diverticulum. The identical twins reported here provide further evidence supporting a genetic predisposition.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2010

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References

1Laing, MR, Murthy, P, Ah-See, KW, Cockburn, JS. Surgery for pharyngeal pouch: audit of management with short- and long-term follow-up. J R Coll Surg Edinb 1995;40:315–18Google Scholar
2van Overbeek, JJ. Pathogenesis and methods of treatment of Zenker's diverticulum. Ann Otol Rhinol Laryngol 2003;112:583–93CrossRefGoogle ScholarPubMed
3Klockars, T, Sihvo, E, Mäkitie, A. Familial Zenker's diverticulum. Acta Otolaryngol 2008;128:1034–6CrossRefGoogle ScholarPubMed
4Marcus, K, Harris, P, Thorne, M, Prince, ME. Familial Zenker's diverticulum: case study and historical perspective. J Otolaryngol 2005;34:437–9Google Scholar
5Keller, KL, Pietrobelli, A, Faith, MS. Genetics of food intake and body composition: lessons from twin studies. Acta Diabetol 2003;40:95100CrossRefGoogle ScholarPubMed
6Munafò, MR, Johnstone, EC. Genes and cigarette smoking. Addiction 2008;103:893904Google Scholar
7Luft, FC. Twins in cardiovascular genetic research. Hypertension 2001;37:350–6CrossRefGoogle ScholarPubMed
8Shiels, A, Hejtmancik, JF. Genetic origins of cataract. Arch Ophthalmol 2007;125:165–73CrossRefGoogle ScholarPubMed
9Pober, BR. Genetic aspects of human congenital diaphragmatic hernia. Clin Genet 2008;74:115Google Scholar