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Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma

Published online by Cambridge University Press:  30 August 2016

A Mishra ,
V Singh ,
V Verma ,
S Pandey ,
R Trivedi ,
H P Singh ,
S Kumar ,
R C Dwivedi  and
S C Mishra
A Mishra*
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
V Singh
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
V Verma
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
S Pandey
Affiliation:
Department of Biochemistry, King George Medical University, Lucknow, India
R Trivedi
Affiliation:
Department of Endocrinology, Central Drug Research Institute, Lucknow, India
H P Singh
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
S Kumar
Affiliation:
Department of Otorhinolaryngology, King George Medical University, Lucknow, India
R C Dwivedi
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, UK
S C Mishra
Affiliation:
Department of Otorhinolaryngology, Nepalgunj Medical College, Kohlpur, Nepal
*
Address for correspondence: Dr Anupam Mishra, Department of Otorhinolaryngology, King George Medical University, Lucknow, India E-mail: amishra_ent@yahoo.com
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Abstract

Objective:

A possible role of the APC/beta-catenin pathway in the pathogenesis of sporadic juvenile nasopharyngeal angiofibroma has been suggested. This paper presents its current status and clinical association in our patients.

Method:

A prospective observational study was conducted at King George Medical University and Central Drug Research Institute, in Lucknow, India. Western blot analysis was undertaken in 16 cases to examine beta-catenin expression. The clinical details were recorded along with follow up observations, to determine associations.

Results:

Up-regulation of beta-catenin expression was seen in 69 per cent of cases. The clinical variables did not reveal significant differences between patients with extremes of expression (extreme under- vs over-expression). However, absent expression was shown exclusively in young adults aged over 18 years, while enhanced expression was associated with an altered facial profile.

Conclusion:

Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.

Keywords

Juvenile Nasopharyngeal AngiofibromaBeta-Catenin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 10 , October 2016 , pp. 907 - 913
Copyright
Copyright © JLO (1984) Limited 2016 

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References

1 Barth, AI, Nathke, IS, Nelson, WJ. Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol 1997;9:683–90CrossRefGoogle ScholarPubMed
2 Behrens, J, von Kries, JP, Kühl, M, Bruhn, L, Wedlich, D, Grosschedl, R et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996;382:638–42Google Scholar
3 Rubinfeld, B, Albert, I, Porfiri, E, Fiol, C, Munemitsu, S, Polakis, P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996;272:1023–6Google Scholar
4 Munemitsu, S, Albert, I, Souza, B, Rubinfeld, B, Polakis, P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 1995;92:3046–50Google Scholar
5 Aberle, H, Bauer, A, Stappert, J, Kispert, A, Kemler, R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997;16:3797–804Google Scholar
6 Orford, K, Crockett, C, Jensen, JP, Weissman, AM, Byers, SW. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem 1997;272:24735–8Google Scholar
7 Morin, PJ, Sparks, AB, Korinek, V, Barker, N, Clevers, H, Vogelstein, B et al. Activation of beta-catenin-Tcf signaling in colon cancers by mutations in beta-catenin or APC. Science 1997;275:1787–90CrossRefGoogle ScholarPubMed
8 Korinek, V, Barker, N, Morin, PJ, van Wichen, D, de Weger, R, Kinzler, KW et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon cancer. Science 1997;275:1784–7Google Scholar
9 Kinzler, KW, Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 1996;87:159–70Google Scholar
10 Sparks, AB, Morin, PJ, Vogelstein, B, Kinzler, KW. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998;58:1130–4Google Scholar
11 Gardner, EJ. Follow-up study of a family group exhibiting dominant inheritance for a syndrome including intestinal polyps, osteomas, fibromas, and epidermal cysts. Am J Hum Genet 1962;14:376–90Google Scholar
12 Klemmer, S, Pascoe, L, DeCosse, J. Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am J Med Genet 1987;28:385–92Google Scholar
13 Krush, AJ, Traboulsi, EI, Offerhaus, GJ, Maumenee, IH, Yardley, JH, Levin, LS. Hepatoblastoma, pigmented ocular fundus lesions and jaw lesions in Gardner syndrome. Am J Med Genet 1988;29:323–32Google Scholar
14 Bell, B, Mazzaferri, EL. Familial adenomatous polyposis (Gardner's syndrome) and thyroid carcinoma: a case report and review of the literature. Dig Dis Sci 1993;38:185–90CrossRefGoogle ScholarPubMed
15 Walsh, N, Qizilbash, A, Banerjee, R, Waugh, GA. Biliary neoplasia in Gardner's syndrome. Arch Pathol Lab Med 1987;111:76–7Google ScholarPubMed
16 Hamilton, SR, Liu, B, Parsons, RE, Papadopoulos, N, Jen, J, Powell, SM et al. The molecular basis of Turcot's syndrome. N Engl J Med 1995;332:839–47Google Scholar
17 Giardiello, FM, Hamilton, SR, Krush, AJ, Offerhaus, JA, Booker, SV, Petersen, GM. Nasopharyngeal angiofibroma in patients with familial adenomatous polyposis. Gastroenterology 1993;105:1550–2Google Scholar
18 Ferouz, AS, Morh, RM, Paul, P. Juvenile nasopharyngeal angiofibroma and familial adenomatous polyposis: an association? Otolaryngol Head Neck Surg 1995;113:435–9.Google Scholar
19 Abraham, SC, Montgomery, EA, Giardiello, FM, Wu, TT. Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. Am J Pathol 2001;158:1073–8Google Scholar
20 Klockars, T, Renkonen, S, Leivo, I, Hagström, J, Mäkitie, AA. Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis. Fam Cancer 2010;9:401–3Google Scholar
21 Lerner, C, Wemmert, S, Schick, B. Preliminary analysis of different microRNA expression levels in juvenile angiofibromas. Biomed Rep 2014;2:835–8Google Scholar
22 Mishra, A, Mishra, SC. Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow, India. J Laryngol Otol 2016;130:363–8CrossRefGoogle Scholar
23 Mishra, SC, Shukla, GK, Bhatia, N, Pant, MC. A rational classification of angiofibromas of the postnasal space. J Laryngol Otol 1989;103:912–16Google Scholar
24 Pawlowski, JE, Ertel, JR, Allen, MP, Xu, M, Butler, C, Wilson, EM et al. Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells. J Biol Chem 2002;277:20702–10CrossRefGoogle ScholarPubMed
25 Valanzano, R, Curia, MC, Aceto, G, Veschi, S, De Lellis, L, Catalano, T et al. Genetic evidence that juvenile nasopharyngeal angiofibroma is an integral FAP tumour. Gut 2005;54:1046–7Google Scholar
26 Guertl, B, Beham, A, Zechner, R, Stammberger, H, Hoefler, G. Nasopharyngeal angiofibroma: an APC-gene associated tumor? Hum Pathol 2000;31:1411–13Google Scholar
27 Garcia-Rostan, G, Tallini, G, Herrero, A, D'Aquila, TG, Carcangiu, ML, Rimm, DL. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma. Cancer Res 1999;59:1811–15Google Scholar
28 Voeller, HJ, Truica, C, Gelmann, EP. Beta-catenin mutations in human prostate cancer. Cancer Res 1998;58:2520–3Google Scholar
29 Fukuchi, T, Sakamoto, M, Tsuda, H, Maruyama, K, Nozawa, S, Hirohashi, S. Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res 1998;58:3526–8Google Scholar
30 Palacios, J, Gamallo, C. Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. Cancer Res 1998;58:1344–7Google ScholarPubMed
31 Mirabelli-Primdahl, L, Gryfe, R, Kim, H, Millar, A, Luceri, C, Dale, D et al. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. Cancer Res 1999;59:3346–51Google Scholar
32 Koesters, R, Ridder, R, Kopp-Schneider, A, Betts, D, Adams, V, Niggli, F et al. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms’ tumors. Cancer Res 1999;59:3880–2Google Scholar
33 Miyoshi, Y, Iwao, K, Nagasawa, Y, Aihara, T, Sasaki, Y, Imaoka, S et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 1998;58:2424–7Google Scholar
34 Huang, H, Fujii, H, Sankila, A, Mahler-Araujo, BM, Matsuda, M, Cathomas, G et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999;155:1795–801Google Scholar
35 Hus, HC, Jeng, YM, Mao, TL, Chu, JS, Lai, PL, Peng, SY. Beta-catenin mutations are associated with a subset of low-grade hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000;157:763–70Google Scholar
36 Zhang, PJ, Weber, R, Liang, H, Pasha, TL, LiVolsi, VA. Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps. Arch Pathol Lab Med 2003;127:1480–4Google Scholar