Hostname: page-component-77c89778f8-vpsfw Total loading time: 0 Render date: 2024-07-21T13:42:48.706Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of denervation on primate laryngeal muscles: a morphologic and morphometric study

Published online by Cambridge University Press:  29 June 2007

V. Sahgal  and
M. H. Hast
V. Sahgal
Affiliation:
Chicago, U.S.A.
M. H. Hast*
Affiliation:
Chicago, U.S.A.
*
Prof. M. H. Hast, Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611.
Get access Rights & Permissions [Opens in a new window]

Abstract

Primate intrinsic laryngeal muscles studied consisted of Type I and Type II fibres. Type II fibres were larger than Type I fibres. The coefficient of variance of these muscles suggested that the fibre-size variation was similar in all of these muscles. Denervation resulted in shrinking of Type II fibres at two weeks in all the muscles, while at four weeks the thyroarytenoid showed an inflammatory reaction and far greater reduction in size than the other muscles. At eight weeks, however, all the muscles were fibrosed. We conclude that laryngeal muscles begin to show evidence of denervation at two weeks and are fibrosed in eight weeks. The thyroarytenoid muscle showed inflammatory degeneration, while the posterior cricoarytenoid and cricothyroid muscles showed classical changes of denervation. These findings should have clinical significance in the timing of reinnervation procedures.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 5 , May 1986 , pp. 553 - 560
Copyright
Copyright © JLO (1984) Limited 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brooke, M. H. and Engel, W. K. (1969) The histographic analysis of human muscle biopsies with regard to fibre type I—adult male and female. Neurology, 19: 221.CrossRefGoogle Scholar
Burke, R. E., Levine, D. N., Zajac, F. E., Tsaris, P. and Engel, W. K. (1971) Mammalian motor units: physiological and histochemical correlation in three types of cat gastrocnemius. Science, 174: 709–711.CrossRefGoogle ScholarPubMed
Drachman, D. A., Wetzel, W., Wasserman, M. and Nito, H. (1969) Experimental denervation of ocular muscles: a critique of the concept of ocular myopathy. Archives of Neurology, 21: 170–183.CrossRefGoogle ScholarPubMed
Hast, M. H. (1969) The primate larynx: a comparative physiological study of intrinsic muscles. Acta Otolaryngologica, 67: 84–92.CrossRefGoogle ScholarPubMed
Javeed, M. M., Herbison, G. J. and Dittuno, J. F. (1975) Denervation and reinnervation of fast and slow muscles (a histochemical study in cats). Journal of Histochemistry and Cytochemistry, 23: 808–827.Google Scholar
Karpati, G. and Engel, W. K. (1968) Histochemical investigation of fibre type ratios with myofibrillary ATPase reaction in normal and denervated skeletal muscles in guinea pig. American Journal of Anatomy, 122: 145–155.CrossRefGoogle Scholar
Malmgren, L. T. and Gacek, R. R. (1981) Histochemical characteristics of muscle fibre types in the posterior cricoarytenoid muscle. Annals of Otology, Rhinology and Laryngology, 90: 423–429.CrossRefGoogle ScholarPubMed
Rosenfeld, D. B., Miller, R. H., Sessions, R. B. and Patten, B. M. (1982) Morphologic and histochemical characteristics of laryngeal muscle. Archives of Otolaryngology, 108: 662–666.CrossRefGoogle Scholar
Sahgal, V. and Hast, M. H. (1974) Histochemistry of primate laryngeal muscles. Acta Otolaryngologica, 78: 277–281.CrossRefGoogle ScholarPubMed
Tucker, H. M. (1984) In Otolaryngology (English, G. M., ed.), vol. 3, chap. 45, 11 p.Google Scholar